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Therefore, this study was designed to investigate the antihyperalgesic, anti\u2010inflammatory, and antioxidant effects of <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> at 5, 10, and 20 mg\/kg of doses via per os (<jats:italic>p.o.)<\/jats:italic> route for 14 days in chronic constriction injury (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>)\u2010induced neuropathic pain in rats. Pain behavior in rats was evaluated before and after <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> administration via mechanical and heat hyperalgesia. <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> caused significant increase in levels of pro\u2010inflammatory cytokines and oxido\u2010nitrosative stress. In addition, significant increase in myeloperoxidase, malondialdehyde, protein carbonyl, nitric oxide (NO), and total oxidant status (TOS) levels in sciatic nerve and spinal cord concomitant with mechanical and heat hyperalgesia is also noted for <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010induced neuropathic pain. Administration of <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> significantly reduced the increased levels of pro\u2010inflammatory cytokines and TOS. Further, reduced glutathione is also restored by <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> also showed in vitro NO and superoxide radical scavenging activity. <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> has a potential in attenuating neuropathic pain behavior in <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> model which may possibly be attributed to its anti\u2010inflammatory and antioxidant properties.<\/jats:p>","DOI":"10.1111\/fcp.12223","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T15:34:56Z","timestamp":1468510496000},"page":"517-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effect of ursolic acid in attenuating chronic constriction injury\u2010induced neuropathic pain in rats"],"prefix":"10.1111","volume":"30","author":[{"given":"Rafia A.","family":"Bhat","sequence":"first","affiliation":[{"name":"Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar 243 122 UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu C.","family":"Lingaraju","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar 243 122 UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitya N.","family":"Pathak","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar 243 122 UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspreet","family":"Kalra","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar 243 122 UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhirendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar 243 122 UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar 243 122 UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra K.","family":"Tandan","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar 243 122 UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2522004re14"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3338-07.2008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1996.16.695"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.2000.0177"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.04.068"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10108"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1723"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.06.008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.08.055"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.08.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/147043"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.11.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.01.017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.12.017"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/np980088i"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900414"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.07.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_6_21_1","first-page":"209","article-title":"A method for measurement of analgesic activity of inflamed tissue","volume":"111","author":"Randall L.O.","year":"1957","journal-title":"Arch. 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