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Previous study demonstrated that AOPPs could accelerate cartilage destruction in rabbit arthritis model. However, the effect of AOPP stimulation on apoptosis of human chondrocyte and the underlying mechanisms remains unclear. This study demonstrated that exposure of chondrocyte to AOPPs resulted in cell apoptosis. AOPP stimulation triggered reactive oxygen species (ROS) production, which induced mitochondrial dysfunction and endoplasmic reticulum stress (ER stress) resulted in caspase activation. Furthermore, an antioxidant, <jats:italic>N<\/jats:italic>\u2010acetylcysteine, markedly blocked these signals. Our study demonstrated that AOPPs induce apoptosis via ROS\u2010related mitochondria\u2010 and ER\u2010dependent signals in human chondrocyte. Targeting AOPP\u2010triggered ROS generation might be as a promising option for patients with RA.<\/jats:p>","DOI":"10.1111\/fcp.12229","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T15:10:23Z","timestamp":1470237023000},"page":"64-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Advanced oxidation protein products induce apoptosis of human chondrocyte through reactive oxygen species\u2010mediated mitochondrial dysfunction and endoplasmic reticulum stress pathways"],"prefix":"10.1111","volume":"31","author":[{"given":"Wenbin","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Spinal Surgery Nanfang Hospital Southern Medical University 1838 North Guangzhou Avenue Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of 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