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This study investigates drugs associated with <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content> in a pharmacovigilance database. <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content> recorded as adverse drug reactions (<jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s) in VigiBase<jats:sup>\u00ae<\/jats:sup>, the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> pharmacovigilance database (more than 11 million reports), from 1978 to 2015 was selected. The risk of <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content> reports was estimated using the case\u2013noncase method, with cases being <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content> and noncases all other recorded <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s. During this 37\u2010year period, 3325 <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s including the word <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content> were registered (0.05% of the database). Mean age was 51.2 \u00b1 16.9 years with 52% men. <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s were \u2018serious\u2019 in around 82% of cases. The case\u2013noncase study found an association between <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content> and exposition with sodium oxybate, rofecoxib, quetiapine, and clozapine for individual drugs and coxibs, antipsychotics, benzodiazepines, and opium alkaloids for drug classes. The potential role of other drugs is discussed. This study suggests that <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content> can be associated with some drugs (mainly psychotropics) that are able to reveal or aggravate such a disease. Physicians should take into account the role of drugs in the etiological appraisal and management of <jats:styled-content style=\"fixed-case\">SAS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/fcp.12264","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T13:42:44Z","timestamp":1483105364000},"page":"359-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Can drugs induce or aggravate sleep apneas? 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