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Glucocorticoid excess, either dependent on the ageing process or iatrogenically induced, was found to additionally impair the bone structure and metabolism. Cautious testosterone supplementation in this respect may positively affect the glucocorticoid milieu and bone homeostasis, while testosterone\u2010induced changes in the glucocorticoid output could serve as a determinant of bone\u2010related therapeutic outcome. Namely, bone mineral content\/density, the parameters of trabecular bone structure as well as bone strength are enhanced, serum calcitonin levels tend to increase, while serum osteocalcin, serum parathyroid hormone and urinary calcium decrease, all upon testosterone administration to the ageing male. In parallel, testosterone application decreases glucocorticoid secretion in the animal models of male ageing, while clinical data in this field are still inconsistent. Importantly, a physiological link exists between testosterone\u2010induced changes in glucocorticoid levels and the tendency of bone status improvement in the ageing male. We believe that the assessment of circulating adrenocorticotropic hormone concentrations together with glucocorticoid levels, reflecting the hypothalamic\u2013pituitary\u2013adrenal axis feedback loop operativeness during testosterone supplementation, represents a well\u2010balanced bone\u2010related therapeutic update.<\/jats:p>","DOI":"10.1111\/fcp.12277","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:28:44Z","timestamp":1486733324000},"page":"372-382","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Testosterone supplementation, glucocorticoid milieu and bone homeostasis in the ageing male"],"prefix":"10.1111","volume":"31","author":[{"given":"Vladimir Z.","family":"Ajd\u017eanovi\u0107","sequence":"first","affiliation":[{"name":"Department of Cytology Institute for Biological Research \u2018Sini\u0161a Stankovi\u0107\u2019 University of Belgrade Despot Stefan Blvd. 142 11060 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branko R.","family":"Filipovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cytology Institute for Biological Research \u2018Sini\u0161a Stankovi\u0107\u2019 University of Belgrade Despot Stefan Blvd. 142 11060 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branka T.","family":"\u0160o\u0161i\u0107 Jurjevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cytology Institute for Biological Research \u2018Sini\u0161a Stankovi\u0107\u2019 University of Belgrade Despot Stefan Blvd. 142 11060 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verica Lj.","family":"Milo\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cytology Institute for Biological Research \u2018Sini\u0161a Stankovi\u0107\u2019 University of Belgrade Despot Stefan Blvd. 142 11060 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367692"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-5-1016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2110"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2015.04.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470846542.ch6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.123552"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-6374(03)00061-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685530400016664"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/13685538.2015.1052392"},{"key":"e_1_2_9_11_1","first-page":"36","article-title":"Somatopause: dismetabolic and bone effects","volume":"28","author":"Lombardi G.","year":"2005","journal-title":"J. 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