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Parachlorophenylalanine (<jats:styled-content style=\"fixed-case\">PCPA<\/jats:styled-content>, 300 mg\/kg\/day, i.p for 3 days)\u2010treated mice were given 6\u2010Hz stimulation. Sodium valproate (<jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>) (200 mg\/kg\/day, p.o for 3 days) was used as a reference antiepileptic drug. The behavioral changes induced by 6 Hz including increased rearing and grooming, Straub's tail, behavioral arrest, stun position were amplified by<jats:styled-content style=\"fixed-case\">PCPA<\/jats:styled-content>. The 6\u2010Hz\u2010induced seizures were accompanied by reduced brain 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>, NE, histamine,<jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>, and enhanced glutamate levels.<jats:styled-content style=\"fixed-case\">PCPA<\/jats:styled-content>facilitated further reduction of endogenous 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>levels but not NE, histamine,<jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>, and glutamate levels. Pre\u2010 and post\u2010treatment with<jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>protected the mice from 6\u2010Hz seizures and attenuated<jats:styled-content style=\"fixed-case\">PCPA<\/jats:styled-content>\u2010induced changes in the levels of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>in the mice brain suggesting the protective effect of<jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>in the pharmacoresistant model of epilepsy involving mainly serotonergic mechanism. However, the study also suggests modulation of other neurotransmitters both in 6\u2010Hz psychomotor seizures and in the action of<jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>against such seizures.<\/jats:p>","DOI":"10.1111\/fcp.12283","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T15:32:42Z","timestamp":1489159962000},"page":"403-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Parachlorophenylalanine\u2010induced 5\u2010<scp>HT<\/scp>depletion alters behavioral and brain neurotransmitters levels in 6\u2010Hz psychomotor seizure model in mice"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3163-2580","authenticated-orcid":false,"given":"Kausar","family":"Jahan","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Jamia Hamdard (Hamdard University) New Delhi 110062 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna K.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Jamia Hamdard (Hamdard University) New Delhi 110062 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Vohora","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Jamia Hamdard (Hamdard University) New Delhi 110062 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"521","volume-title":"The pharmacological basis of therapeutics","author":"Jo M.","year":"2011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02397.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(01)00302-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815111"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(94)90130-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03290.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00474-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05296.x"},{"volume-title":"Basic mechanisms underlying seizures and epilepsy","year":"2006","author":"Bromfield E.B.","key":"e_1_2_8_10_1"},{"key":"e_1_2_8_11_1","first-page":"531","article-title":"Genetic animal models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs. 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