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A 45\u2010year\u2010old male Caucasian patient developed agranulocytosis caused by dapsone (diamino\u2010diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, antibiotic therapy, and granulocyte colony\u2010stimulating factor leading to prompt improvement of symptoms and normalization of laboratory blood values. Diagnostic evaluation revealed methemoglobinemia and excluded glucose\u20106\u2010phosphate dehydrogenase deficiency. Pharmacogenetics testing showed that he was a carrier of<jats:italic><jats:styled-content style=\"fixed-case\">NAT<\/jats:styled-content>2 *5\/*6<\/jats:italic>genotype, predisposing to low activity of the<jats:italic>N<\/jats:italic>\u2010acetyltransferase 2 enzyme. This was the first and only<jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>to dapsone reported in Croatia. In total, there have been 73<jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>to dapsone recorded worldwide, including only four cases of agranulocytosis.<\/jats:p>","DOI":"10.1111\/fcp.12287","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T05:48:11Z","timestamp":1490161691000},"page":"580-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dapsone\u2010induced agranulocytosis\u2014possible involvement of low\u2010activity<i>N<\/i>\u2010acetyltransferase 2"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-9669","authenticated-orcid":false,"given":"Ines","family":"Poto\u010dnjak","sequence":"first","affiliation":[{"name":"Clinical Unit of Clinical Pharmacology and Toxicology Department of Medicine University Hospital Centre Sisters of Charity Vinogradska cesta 10 000 Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Liki\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine \u0160alata 3 10 000 Zagreb Croatia"},{"name":"Division of Clinical Pharmacology Department of Internal Medicine University Hospital Centre Zagreb Ki\u0161pati\u0107eva 12 10 000 Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iveta","family":"\u0160imi\u0107","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine \u0160alata 3 10 000 Zagreb Croatia"},{"name":"Division of Clinical Pharmacology Department of Internal Medicine University Hospital Centre Zagreb Ki\u0161pati\u0107eva 12 10 000 Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danica","family":"Juri\u010di\u0107 Nahal","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Internal Medicine University Hospital Centre Zagreb Ki\u0161pati\u0107eva 12 10 000 Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"\u010cegec","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Department of Internal Medicine University Hospital Centre Zagreb Ki\u0161pati\u0107eva 12 10 000 Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Ganoci","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine \u0160alata 3 10 000 Zagreb Croatia"},{"name":"Department of Laboratory Diagnostics University Hospital Centre Zagreb Ki\u0161pati\u0107eva 12 10 000 Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Bo\u017eina","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine \u0160alata 3 10 000 Zagreb Croatia"},{"name":"Department of Laboratory Diagnostics University Hospital Centre Zagreb Ki\u0161pati\u0107eva 12 10 000 Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"unstructured":"UpToDate\u00ae.Wolters Kluwer Health. 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