{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:44:21Z","timestamp":1760550261534,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An external evaluation of phenobarbital population pharmacokinetic model described by Marsot et al. was performed in pediatric intensive care unit. Model evaluation is an important issue for dose adjustment. This external evaluation should allow confirming the proposed dosage adaptation and extending these recommendations to the entire intensive care pediatric population. External evaluation of phenobarbital published population pharmacokinetic model of Marsot et al. was realized in a new retrospective dataset of 35 patients hospitalized in a pediatric intensive care unit. The published population pharmacokinetic model was implemented in <jats:sc>nonmem<\/jats:sc> 7.3. Predictive performance was assessed by quantifying bias and inaccuracy of model prediction. Normalized prediction distribution errors (<jats:styled-content style=\"fixed-case\">NPDE<\/jats:styled-content>) and visual predictive check (<jats:styled-content style=\"fixed-case\">VPC<\/jats:styled-content>) were also evaluated. A total of 35 infants were studied with a mean age of 33.5 weeks (range: 12 days\u201316 years) and a mean weight of 12.6 kg (range: 2.7\u201370.0 kg). The model predicted the observed phenobarbital concentrations with a reasonable bias and inaccuracy. The median prediction error was 3.03% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22128.52 to 58.12%), and the median absolute prediction error was 26.20% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 13.07\u201375.59%). No trends in <jats:styled-content style=\"fixed-case\">NPDE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">VPC<\/jats:styled-content> were observed. The model previously proposed by Marsot et al. in neonates hospitalized in intensive care unit was externally validated for <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> infusion administration. The model\u2010based dosing regimen was extended in all pediatric intensive care unit to optimize treatment. Due to inter\u2010 and intravariability in pharmacokinetic model, this dosing regimen should be combined with therapeutic drug monitoring.<\/jats:p>","DOI":"10.1111\/fcp.12291","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T18:04:14Z","timestamp":1492106654000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Phenobarbital in intensive care unit pediatric population: predictive performances of population pharmacokinetic model"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-8862","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Marsot","sequence":"first","affiliation":[{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Pharmacologie Int\u00e9gr\u00e9e et Interface Clinique Industrielle Institut des Neurosciences Timone \u2013 AMU\u2010CNRS 7289 Aix\u2010Marseille Universit\u00e9 AP\u2010HM Hopital Timone \u2013 B\u00e2timent F 264 rue Saint Pierre Marseille 13385 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Michel","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation P\u00e9diatrique AP\u2010HM Hopital Timone 264 rue saint pierre Marseille 13385 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estelle","family":"Chasseloup","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Pharmacologie Int\u00e9gr\u00e9e et Interface Clinique Industrielle Institut des Neurosciences Timone \u2013 AMU\u2010CNRS 7289 Aix\u2010Marseille Universit\u00e9 AP\u2010HM Hopital Timone \u2013 B\u00e2timent F 264 rue Saint Pierre Marseille 13385 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Paut","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation P\u00e9diatrique AP\u2010HM Hopital Timone 264 rue saint pierre Marseille 13385 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Guilhaumou","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Pharmacologie Int\u00e9gr\u00e9e et Interface Clinique Industrielle Institut des Neurosciences Timone \u2013 AMU\u2010CNRS 7289 Aix\u2010Marseille Universit\u00e9 AP\u2010HM Hopital Timone \u2013 B\u00e2timent F 264 rue Saint Pierre Marseille 13385 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Blin","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Pharmacologie Int\u00e9gr\u00e9e et Interface Clinique Industrielle Institut des Neurosciences Timone \u2013 AMU\u2010CNRS 7289 Aix\u2010Marseille Universit\u00e9 AP\u2010HM Hopital Timone \u2013 B\u00e2timent F 264 rue Saint Pierre Marseille 13385 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03788.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-720X.2000.tb00687.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMhpr021646"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7227.79"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"TreluyerJ.M. 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