{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:43:47Z","timestamp":1788637427098,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dihydropyridine calcium\u2010channel blockers are a known substrate for the cytochrome P450 isoform 3A4. Rifampicin, an antitubercular agent, is one of the most potent inducers of hepatic and intestinal<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3A4 thus increasing dihydropyridine metabolism. We report a case of a 67\u2010year\u2010old hypertensive female treated with a four\u2010drug antihypertensive regimen including a dihydropyridine (nicardipine 50\u00a0mg bid), who was admitted for septic arthritis of the knee requiring antibiotic treatment with teicoplanin 400\u00a0mg od and rifampicin 600\u00a0mg bid. Six days after rifampicin initiation, she presented with Posterior Reversible Encephalopathy Syndrome due to uncontrolled hypertension. We hypothesized that disequilibrium of previously controlled hypertension was partially due to nicardipine ineffectiveness. Plasma nicardipine concentration was assessed through high\u2010performance liquid chromatography 5 hours after coadministration of the two drugs and proved undetectable.<\/jats:p>","DOI":"10.1111\/fcp.12292","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T17:11:46Z","timestamp":1492103506000},"page":"587-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Rifampicin reverses nicardipine effect inducing uncontrolled essential hypertension"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5502-542X","authenticated-orcid":false,"given":"Elena\u2010Mihaela","family":"Cordeanu","sequence":"first","affiliation":[{"name":"Department of Hypertension Vascular Disease and Clinical Pharmacology Strasbourg Regional University Hospital Strasbourg BP 426, 67091 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Gaertner","sequence":"additional","affiliation":[{"name":"Department of Hypertension Vascular Disease and Clinical Pharmacology Strasbourg Regional University Hospital Strasbourg BP 426, 67091 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Faller","sequence":"additional","affiliation":[{"name":"Department of Hypertension Vascular Disease and Clinical Pharmacology Strasbourg Regional University Hospital Strasbourg BP 426, 67091 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Mirea","sequence":"additional","affiliation":[{"name":"Department of Hypertension Vascular Disease and Clinical Pharmacology Strasbourg Regional University Hospital Strasbourg BP 426, 67091 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Lessinger","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Strasbourg Regional University Hospital Strasbourg BP 426, 67091 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Kemmel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Strasbourg Regional University Hospital Strasbourg BP 426, 67091 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Stephan","sequence":"additional","affiliation":[{"name":"Department of Hypertension Vascular Disease and Clinical Pharmacology Strasbourg Regional University Hospital Strasbourg BP 426, 67091 France"},{"name":"Regional Pharmacovigilance Centre Strasbourg BP 426, 67091 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342090-00003"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2011.00990.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.206"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01200.x"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038010-00003"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.038067"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00110a012"},{"key":"e_1_2_3_9_1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0090-9556(25)08415-6","article-title":"The nifedipine\u2010rifampin interaction. 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