{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:20:48Z","timestamp":1771615248027,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20102 and matrix metalloproteinase\u20109 are involved in many illnesses affecting pregnant women, including intrahepatic cholestasis of pregnancy (<jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>), a serious liver abnormality during pregnancy. Epigallocatechin\u20103\u2010gallate (<jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content>) has been widely reported to inhibit activities of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109. We aimed to investigate the role of <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> in ameliorating <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> symptoms in a rat model. Using 17\u03b1\u2010ethinylestradiol to induce <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> in pregnant rats, we investigated the efficacy of <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> administration on <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> symptoms, including bile flow rate, total bile acids (<jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 activities. Correlation study was conducted among levels of the two <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s with other <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> symptoms. In <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> rats, activities of both <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 were significantly elevated. <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> administration could inhibit the upregulation of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 post\u2010transcriptionally. Furthermore, <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> ameliorated <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> symptoms, as evidenced by restored bile flow rate and <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>, showing efficient treatment outcomes. At last, levels of <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content> and the two <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s were found to be strongly correlated. Our study demonstrates that, for the first time, the efficacy of <jats:styled-content style=\"fixed-case\">EGCG<\/jats:styled-content> in ameliorating <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content> symptoms by inhibiting both <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109, which supports its potential as a novel drug in ameliorating <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/fcp.12294","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T01:40:31Z","timestamp":1494034831000},"page":"526-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Epigallocatechin\u20103\u2010gallate ameliorates intrahepatic cholestasis of pregnancy by inhibiting matrix metalloproteinase\u20102 and matrix metalloproteinase\u20109"],"prefix":"10.1111","volume":"31","author":[{"given":"Mei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Liaocheng People's Hospital No. 67 of Dongchang West Road Liaocheng 252000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0918-9180","authenticated-orcid":false,"given":"Meimei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Liaocheng People's Hospital No. 67 of Dongchang West Road Liaocheng 252000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1997.tb00410.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20336"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005237-200507000-00007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90922-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200201000-00023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-26"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(03)00131-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211545"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80139-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22139"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13557859998173"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21156"},{"key":"e_1_2_8_15_1","first-page":"60","article-title":"Amniotic fluid bile acids in normal and pathologic pregnancy","volume":"56","author":"Heikkinen J.","year":"1980","journal-title":"Obstet. 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