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Recently, we demonstrated the potential antinociceptive and anti\u2010inflammatory of 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content>. For this reason, the first objective of this study was to expand our previous findings by investigating the contribution of glutamatergic, serotonergic, and nitrergic systems to the acute antinociceptive action of this compound. Pretreatment with 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content> (0.01\u201325 mg\/kg, p.o.) reduced the nociception induced by glutamate. <jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>\u2010801 (an uncompetitive antagonist of the <jats:italic>N<\/jats:italic>\u2010Methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (<jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>) receptor) blocked the antinociceptive effect exerted by 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content> (25 mg\/kg, p.o.) in the acetic acid\u2010induced abdominal writhing test. The pretreatment with <jats:styled-content style=\"fixed-case\">WAY<\/jats:styled-content>100635 (a selective antagonist of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1A<\/jats:sub> receptor), ketanserin (a selective antagonist of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>2A\/2C<\/jats:sub> receptor), and pindolol (a nonselective antagonist of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1A\/1B<\/jats:sub> receptors) partially blocked the antinociceptive effect caused by 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content> (25 mg\/kg, per oral, p.o.) in the acetic acid\u2010induced abdominal writhing test. Nitric oxide precursor, <jats:sc>l<\/jats:sc>\u2010arginine hydrochloride, partially reversed antinociception caused by 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content> or \u03c9\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine (<jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">NOARG<\/jats:styled-content>). Treatments did not modify the locomotor and exploratory activities of mice. Additionally, the acute anti\u2010inflammatory effect of 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content> in a model of pleurisy induced by carrageenan in mice was investigated. 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content> reduced the cellular migration, pleural exudate accumulation, and myeloperoxidase activity induced by carrageenan exposure. 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content> protected against the increase in reactive species levels and reduction of nonprotein thiol levels induced by carrageenan. Data presented here showed that the modulation of serotonergic, nitrergic, and glutamatergic systems contributed to the antinociceptive effect of 4\u2010<jats:styled-content style=\"fixed-case\">PSQ<\/jats:styled-content> and it reinforced the therapeutic potential of this quinolinic compound for acute inflammation.<\/jats:p>","DOI":"10.1111\/fcp.12295","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T01:07:10Z","timestamp":1495588030000},"page":"513-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Further analysis of acute antinociceptive and anti\u2010inflammatory actions of 4\u2010phenylselenyl\u20107\u2010chloroquinoline in mice"],"prefix":"10.1111","volume":"31","author":[{"given":"Vanessa D. G.","family":"Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Farmacologia Bioqu\u00edmica \u2010 LaFarBio \u2010 Grupo de Pesquisa em Neurobiotecnologia CCQFA \u2010 Universidade Federal de Pelotas UFPel \u2010 P.O. Box 354 96010\u2010900 Pelotas RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica S.","family":"Reis","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Farmacologia Bioqu\u00edmica \u2010 LaFarBio \u2010 Grupo de Pesquisa em Neurobiotecnologia CCQFA \u2010 Universidade Federal de Pelotas UFPel \u2010 P.O. Box 354 96010\u2010900 Pelotas RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaela P.","family":"Pinz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Farmacologia Bioqu\u00edmica \u2010 LaFarBio \u2010 Grupo de Pesquisa em Neurobiotecnologia CCQFA \u2010 Universidade Federal de Pelotas UFPel \u2010 P.O. Box 354 96010\u2010900 Pelotas RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren A. R.","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Farmacologia Bioqu\u00edmica \u2010 LaFarBio \u2010 Grupo de Pesquisa em Neurobiotecnologia CCQFA \u2010 Universidade Federal de Pelotas UFPel \u2010 P.O. Box 354 96010\u2010900 Pelotas RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Fernando B.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese Org\u00e2nica Limpa \u2010 LASOL \u2010 CCQFA \u2010 Universidade Federal de Pelotas UFPel \u2010 P.O. Box 354 96010\u2010900 Pelotas RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano A.","family":"Roehrs","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese Org\u00e2nica Limpa \u2010 LASOL \u2010 CCQFA \u2010 Universidade Federal de Pelotas UFPel \u2010 P.O. Box 354 96010\u2010900 Pelotas RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Alves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese Org\u00e2nica Limpa \u2010 LASOL \u2010 CCQFA \u2010 Universidade Federal de Pelotas UFPel \u2010 P.O. 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