{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:58:57Z","timestamp":1769605137848,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Benign prostatic hyperplasia (<jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content>) is a common health problem in ageing men. This study was carried out to investigate the protective effect of telmisartan on testosterone\u2010induced<jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content>in rats. Fifty\u2010four male Wistar rats (200\u2013250 g) were randomly divided into nine groups (<jats:italic>n<\/jats:italic>= 6) and orally treated for 28 consecutive days: group 1 \u2013 vehicle normal, olive oil (10 mL\/kg); group 2 \u2013<jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content>model control (10 mL\/kg); groups 3\u20135 \u2013 telmisartan (5, 10 or 20 mg\/kg, respectively); group 6 \u2013 pioglitazone (20 mg\/kg); group 7 \u2013 celecoxib (20 mg\/kg); group 8 \u2013 combination of telmisartan (5 mg\/kg) and pioglitazone (20 mg\/kg); group 9 \u2013 combination of telmisartan (5 mg\/kg) and celecoxib (20 mg\/kg). Animals in groups 2\u20139 were given testosterone propionate in olive oil (3 mg\/kg) subcutaneously 15 min after pretreatments. On day 29, blood was collected for the estimation of serum testosterone and prostate\u2010specific antigen (<jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>). The prostates were excised, weighed and subjected to biochemical and histological studies. Testosterone injection induced significant increase in prostatic index, serum testosterone and<jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>suggesting<jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content>as well as increased prostate oxidative stress which were ameliorated with the pretreatment of rats with telmisartan or co\u2010administration of celecoxib and pioglitazone. Histological examination showed that testosterone disrupted the morphology of the prostate epithelial cells evidenced in the involution of the epithelial lining of the acini into the lumen indicating<jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content>which was reversed by telmisartan. Findings from this study showed that telmisartan alone or in combination with pioglitazone prevented the development of testosterone\u2010induced prostatic hyperplasia.<\/jats:p>","DOI":"10.1111\/fcp.12304","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T16:22:39Z","timestamp":1500567759000},"page":"643-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Potential of telmisartan in the treatment of benign prostatic hyperplasia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-6754","authenticated-orcid":false,"given":"Ismail Ogunbayode","family":"Ishola","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology Faculty of Basic Medical Sciences College of Medicine University of Lagos Lagos Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles C.","family":"Anunobi","sequence":"additional","affiliation":[{"name":"Department of Anatomic and Molecular Pathology Faculty of Basic Medical Sciences College of Medicine University of Lagos Lagos Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kehinde Habeeb","family":"Tijani","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Unit Faculty of Clinical Sciences College of Medicine University of Lagos Lagos Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olasunmbo","family":"Afolayan","sequence":"additional","affiliation":[{"name":"Department of Anatomy Faculty of Basic Medical Sciences College of Medicine University of Lagos Lagos Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria U.","family":"Udokwu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology Faculty of Basic Medical Sciences College of Medicine University of Lagos Lagos Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2012.53.3.139"},{"key":"e_1_2_8_3_1","first-page":"14","article-title":"Benign prostatic hyperplasia and lower urinary tract symptoms: evidence and approaches for best case management","volume":"18","author":"Barkin J.","year":"2011","journal-title":"Can. 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