{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:24:18Z","timestamp":1790641458625,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["2015030"],"award-info":[{"award-number":["2015030"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we investigated the effect of bufalin on the human ether\u2010\u00e0\u2010go\u2010go\u2010related gene (<jats:styled-content style=\"fixed-case\">hERG<\/jats:styled-content>) K<jats:sup>+<\/jats:sup> channels using the perforated patch recording technique. We measured a half\u2010maximal inhibitory concentration (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub>) of 24.83 \u03bc<jats:sc>M<\/jats:sc> and maximal inhibitory effect of 39.45 \u00b1 1.14% with bufalin. These findings suggest that bufalin is a potent <jats:styled-content style=\"fixed-case\">hERG<\/jats:styled-content> K<jats:sup>+<\/jats:sup> channel blocker and may provide a new way for understanding Chan Su\u2010induced arrhythmia.<\/jats:p>","DOI":"10.1111\/fcp.12306","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T15:06:38Z","timestamp":1501340798000},"page":"695-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses <scp>hERG<\/scp> K<sup>+<\/sup> currents expressed in <scp>HEK<\/scp>293 cells"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3988-3536","authenticated-orcid":false,"given":"Tao","family":"Song","sequence":"first","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"},{"name":"Hebei key laboratory of integrative Medicine on Liver\u2010Kidney Patterns Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongtao","family":"Song","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjiang","family":"Guan","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"},{"name":"Hebei key laboratory of integrative Medicine on Liver\u2010Kidney Patterns Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Fourth Hospital of Hebei Medical University No. 12, Jiankang Road Shijiazhuang 050011 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"},{"name":"Hebei key laboratory of integrative Medicine on Liver\u2010Kidney Patterns Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chu","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine No. 3, Xingyuan Road Shijiazhuang 050200 Hebei China"},{"name":"Hebei key laboratory of integrative Medicine on Liver\u2010Kidney Patterns Shijiazhuang 050200 Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1992.tb07086.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000450754"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160734"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00696.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00966.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2017.01.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22325"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.35.4996"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-185"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12265"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199802000-00019"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2011.583295"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03337.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706892"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707537"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(98)77782-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.02.013"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00008.2002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.12.012"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143797"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(89)90435-6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08102FP"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00715-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12267"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12174"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.07.056"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12284"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980000000525"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12222"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12186"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2004.00301.x"},{"key":"e_1_2_7_33_1","first-page":"3659","article-title":"Reevaluation on adverse reaction monitoring and safety of proprietary Chinese medicines of chongqing from 2005 to 2011","volume":"37","author":"Yang Y.Y.","year":"2012","journal-title":"China J. Chin. Materia Med."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X92000254"},{"key":"e_1_2_7_35_1","first-page":"289","article-title":"Cardiac toxicity of resibufogenin: electrophysiological evidence","volume":"22","author":"Xie J.T.","year":"2001","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffcp.12306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:49:49Z","timestamp":1695980989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/fcp.12306"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12306","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]},"assertion":[{"value":"2017-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}