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Of the various<jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate antagonists that are alternatives to be recommended in first\u2010line<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>treatment, memantine has the safest side\u2010effect profile and has long been approved in Alzheimer's disease. The review covers memantine studies in postherpetic neuralgia, diabetic pain, postoperative pain, complex regional pain syndrome, chronic phantom limb pain, opioid\u2010refractory pain and fibromyalgia. Results were inconclusive because of studies with poor levels of evidence, paucity of trials and small samples. Two recent randomized trials, however, showed significant efficacy of memantine: one demonstrated prophylactic effects against postoperative neuralgia and pain\u2010associated psychological impairment; in the other, memantine improved pain and cognition in fibromyalgia. Both studies found no side effects or adverse events. Given the high rate of therapeutic failure in chronic states, often because of adverse events, the excellent benefit\/risk ratio of memantine in these pilot studies encourages further exploration of this drug in<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>prevention and in fibromyalgia in larger\u2010scale studies.<\/jats:p>","DOI":"10.1111\/fcp.12316","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T13:42:37Z","timestamp":1502545357000},"page":"4-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Memantine for the treatment of general neuropathic pain: a narrative review"],"prefix":"10.1111","volume":"32","author":[{"given":"Gis\u00e8le","family":"Pickering","sequence":"first","affiliation":[{"name":"CHU Clermont\u2010Ferrand Centre de Pharmacologie Clinique F\u201063003 Clermont\u2010Ferrand France"},{"name":"Inserm, CIC 1405 Neurodol 1107 F\u201063003 Clermont\u2010Ferrand France"},{"name":"Laboratoire de Pharmacologie Facult\u00e9 de M\u00e9decine Clermont Universit\u00e9 F\u201063001 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0363-1089","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Morel","sequence":"additional","affiliation":[{"name":"CHU Clermont\u2010Ferrand Centre de Pharmacologie Clinique F\u201063003 Clermont\u2010Ferrand France"},{"name":"Inserm, CIC 1405 Neurodol 1107 F\u201063003 Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,4]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Part III: pain terms. 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