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We recently reported the role of intradermal nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>)\/cyclic guanosine monophosphate pathway in<jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>\u2010evoked scratching in mice. Chloroquine stimulates neuronal nitric oxide synthase (<jats:styled-content style=\"fixed-case\">nNOS<\/jats:styled-content>) activity to over\u2010producing<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>in the skin. Sumatriptan, a 5\u2010hydroxytryptamine 1b\/1d receptors (5\u2010<jats:styled-content style=\"fixed-case\">HTR<\/jats:styled-content>1b\/1d) agonist, is involved in pain and used to treat migraine and cluster headaches. According to previous studies, sumatriptan inhibits<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>activity. Thus, we aimed to investigate the effect of sumatriptan on<jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>\u2010induced scratching. We used the rostral back model of itch. Chloroquine was injected intradermally into the rostral back of<jats:styled-content style=\"fixed-case\">NMRI<\/jats:styled-content>mice, and the scratching behavior was evaluated by measuring the number of bouts over 30 min. We evaluated the effect of sumatriptan and combination of sumatriptan and a non\u2010selective<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>synthase inhibitor, L\u2010N\u2010nitro arginine methyl ester (L\u2010<jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content>), on the scratching behavior. Additionally, the changes of skin, hippocampus, and cortical nitrite level after different treatments were studied. Intraperitoneal and intradermal sumatriptan attenuates<jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>\u2010induced itch which reversed by<jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content>\u2010127935, the selective 5\u2010<jats:styled-content style=\"fixed-case\">HTR<\/jats:styled-content>1b and 5\u2010<jats:styled-content style=\"fixed-case\">HTR<\/jats:styled-content>1d antagonist. Co\u2010administration of subeffective doses of sumatriptan and L\u2010<jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content>significantly decreases the scratching behavior. Intradermal injection of<jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>significantly increases the intradermal nitrite levels while it does not have any significant effects on hippocampal or cortical nitrite concentrations. Likewise, the effective doses of intraperitoneal and intradermal sumatriptan significantly reduce intradermal nitrite levels. We concluded that sumatriptan suppresses<jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>\u2010induced itch most likely by activating 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>1b\/1d receptors. This effect probably mediates through<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>pathway.<\/jats:p>","DOI":"10.1111\/fcp.12317","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T07:55:52Z","timestamp":1502956552000},"page":"69-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacological evidence of involvement of nitric oxide pathway in anti\u2010pruritic effects of sumatriptan in chloroquine\u2010induced scratching in mice"],"prefix":"10.1111","volume":"32","author":[{"given":"Nazgol\u2010Sadat","family":"Haddadi","sequence":"first","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sattar","family":"Ostadhadi","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"},{"name":"Brain and Spinal Cord Injury Research Center Neuroscience Institute Tehran University of Medical Sciences Chamran highway Bagherkhan St., Imam Khomeini Hospital Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Shakiba","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khashayar","family":"Afshari","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastaran","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Foroutan","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-5565","authenticated-orcid":false,"given":"Ahmad\u2010Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Poorsina St., Enghelab Ave. Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0806"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1950"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.178"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00664.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(89)90391-7","article-title":"Pruritus and antimalarial drugs in Africans","volume":"334","author":"Sowunmi A.","year":"1989","journal-title":"Lancet"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00483-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"12818","DOI":"10.1074\/jbc.M113.450072","article-title":"Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel\u2010expressing sensory neurons by the pruritogen chloroquine","volume":"288","author":"Jonathan Y.\u2010X.","year":"2013","journal-title":"J. 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