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Although blockade of L\u2010type Ca<jats:sup>2+<\/jats:sup> channels by amlodipine (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) has been shown to suppress hepatic I\/R injury in several animal models, information is still needed regarding the hepatoprotective effects of the dual L\/N\u2010type Ca<jats:sup>2+<\/jats:sup> channel blockers, cilnidipine (<jats:styled-content style=\"fixed-case\">CIL<\/jats:styled-content>). We examined the effect of pretreatment with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CIL<\/jats:styled-content> (100 \u03bcg\/kg i.p.) 45 min before induction of 60 min of liver ischemia followed by reperfusion, on oxidative stress markers, liver enzymes, serum tumor necrosis factor\u2010\u03b1, interleukin\u20101\u03b2, apoptosis markers, and nuclear factor <jats:styled-content style=\"fixed-case\">KB<\/jats:styled-content> after 6 and 24 h of hepatic reperfusion. Both drugs significantly ameliorated biochemical and histological markers of hepatic I\/R injury, but protection with <jats:styled-content style=\"fixed-case\">CIL<\/jats:styled-content> was more significant at the 6\u2010h time point where protection with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> outlasted that of <jats:styled-content style=\"fixed-case\">CIL<\/jats:styled-content>. Both drugs offered significant protection against hepatic I\/R damage, but the protection with <jats:styled-content style=\"fixed-case\">CIL<\/jats:styled-content> seemed more potent but of shorter duration than that observed with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> possibly due to the shorter half\u2010life of <jats:styled-content style=\"fixed-case\">CIL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/fcp.12335","type":"journal-article","created":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T00:02:44Z","timestamp":1511568164000},"page":"163-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative study of amlodipine vs. cilnidipine for the prevention of hepatic ischemia\u2010reperfusion injury in rat model"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4962-9817","authenticated-orcid":false,"given":"Abdel\u2010Motaal","family":"Fouda","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Faculty of Medicine Mansoura University 35516 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany R.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Mansoura University 35516 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Sharaf Eldin","sequence":"additional","affiliation":[{"name":"Pathology Department Weston General Hospital Grange Road BS23 4TQ UK"},{"name":"Pathology Department Faculty of Medicine Mansoura University 35516 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2507"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.225"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/08941939.2010.496036"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s595-002-8105-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816fefb5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12229"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i11.1683"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10007-008-0022-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199507150-00005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1996.0321"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000473"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2009.00079.x"},{"key":"e_1_2_6_16_1","first-page":"591","article-title":"Protective effects of amlodipine on mitochondrial injury in ischemic reperfused rat heart","volume":"33","author":"Khan N.A.","year":"2012","journal-title":"J. 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