{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:41:03Z","timestamp":1774557663652,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007543","name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pregnancy can be a motivation for decrease in drug abusing but may also represent a period of high vulnerability for relapse. We aimed to assess psychoactive substance use among women with substance use disorders followed in addiction care centers in France. We analyzed data from women aged 15\u201344 years included in the \u2018Observation of illegal drugs and misuse of psychotropic medication (<jats:styled-content style=\"fixed-case\">OPPIDUM<\/jats:styled-content>) survey\u2019, an annual cross\u2010sectional survey collecting details on psychoactive substances used. Characteristics of women included in 2005\u20132012 yearly surveys were compared depending on their pregnant or not pregnant status. Factors, including pregnancy, associated with illicit substance use and medication misuse were investigated through logistic regression. The study included 518 pregnant and 6345 nonpregnant women; 85.3% pregnant women were on opioid maintenance therapy (OMT) (vs. 77.1% of nonpregnant). Pregnancy was associated with lower illicit substance use (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.71 [0.58\u20130.88]) and with lower medication misuse (0.66 [0.49\u20130.89]), whereas financial insecurity and living as a couple were associated with increased risk. Raising children was significantly associated with less risk of substance use. Each substance taken separately, the part of women using illicit substance or misusing medication did not differ depending on whether they were pregnant or not, except for heroin (24.5% in pregnant vs. 17.9% nonpregnant; &lt;0.001). This nationwide study provides new insights into psychoactive substance use in a large mixed population of women with drug use disorders. Results outline the challenge of preventing drug use and initiating care strategies with a specific approach on socio\u2010economic environment.<\/jats:p>","DOI":"10.1111\/fcp.12346","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T16:31:35Z","timestamp":1516120295000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of pregnancy on psychoactive substance use among women with substance use disorders recruited in addiction specialized care centers in France"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9271-5278","authenticated-orcid":false,"given":"Liselotte","family":"Pochard","sequence":"first","affiliation":[{"name":"Service de Pharmacologie Clinique Facult\u00e9 de M\u00e9decine Centre d'Evaluation et d'Information sur la Pharmacod\u00e9pendance\u2010Addictovigilance de Toulouse CHU de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"},{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Centre d'Evaluation et d'Information sur la Pharmacod\u00e9pendance Paca Corse H\u00f4pital de la Timone 13005 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Dupouy","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine UMR Inserm 1027 Universit\u00e9 Toulouse 3 37 All\u00e9es Jules Guesde 31073 Toulouse Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Frauger","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Centre d'Evaluation et d'Information sur la Pharmacod\u00e9pendance Paca Corse H\u00f4pital de la Timone 13005 Marseille France"},{"name":"Institut de Neurosciences de la Timone UMR 7289 CNRS Aix\u2010Marseille Universit\u00e9 Campus Timone 13005 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline","family":"Giocanti","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Centre d'Evaluation et d'Information sur la Pharmacod\u00e9pendance Paca Corse H\u00f4pital de la Timone 13005 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-7835","authenticated-orcid":false,"given":"Jo\u00eblle","family":"Micallef","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Centre d'Evaluation et d'Information sur la Pharmacod\u00e9pendance Paca Corse H\u00f4pital de la Timone 13005 Marseille France"},{"name":"Institut de Neurosciences de la Timone UMR 7289 CNRS Aix\u2010Marseille Universit\u00e9 Campus Timone 13005 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-5873","authenticated-orcid":false,"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique Facult\u00e9 de M\u00e9decine Centre d'Evaluation et d'Information sur la Pharmacod\u00e9pendance\u2010Addictovigilance de Toulouse CHU de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"},{"name":"Facult\u00e9 de M\u00e9decine UMR Inserm 1027 Universit\u00e9 Toulouse 3 37 All\u00e9es Jules Guesde 31073 Toulouse Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"French Addictovigilance Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3282f1bf17"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.121073"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02588-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2005.10.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.02.027"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2011.00950.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2263"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12233"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2015009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12210"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12172"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2010.01.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.94.2.266"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00030-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2000.95811411.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.07.010"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(00)00152-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39514.554375.AE"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1049-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.08.011"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.07.004"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109348165"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1980.tb05628.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7162.839"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.10.1106"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12209"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02423-X"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(01)00136-8"},{"issue":"340","key":"e_1_2_6_31_1","first-page":"e1","article-title":"Knowledge synthesis group on determinants of low birth weight and preterm births. Effects of cocaine use during pregnancy on low birthweight and preterm birth: systematic review and metaanalyses","volume":"204","author":"Gouin K.","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2011.25"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(03)00035-7"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00740.x"},{"key":"e_1_2_6_35_1","volume-title":"Pregnant women and drugs. Combating stereotype and stigma","author":"Murphy S.","year":"2009"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2012.01.004"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffcp.12346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:28:54Z","timestamp":1695572934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,29]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/fcp.12346"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12346","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,29]]},"assertion":[{"value":"2017-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}