{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:33:08Z","timestamp":1790645588863,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T00:00:00Z","timestamp":1531612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>4\u2010Aminopyridine (4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>) is a recent treatment indicated to improve walking in patient with multiple sclerosis. We report the first case of pulmonary arterial hypertension (<jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>) that we attribute to the use of 4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>. A 64\u2010year\u2010old woman with multiple sclerosis presented with dyspnea. After excluding other secondary causes of pulmonary hypertension, a diagnosis of severe <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> due to 4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> was made based on right heart catheterization. History revealed that the dyspnea began with the initiation of 4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>. After discontinuation of 4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> therapy and initiation of ambrisentan and tadalafil, dyspnea and pulmonary arterial pressure have improved significantly and one specific <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> treatment was stopped. 4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> is an outward rectifying potassium channel blocker with a vasoconstrictor effect in animal's pulmonary artery. According to the chronological sequence of events, the lack of other etiology, and its pharmacological plausibility, 4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> is highly suspected to have induced our patient's <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/fcp.12396","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T11:23:16Z","timestamp":1530271396000},"page":"127-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pulmonary arterial hypertension in patient treated for multiple sclerosis with 4\u2010aminopyridine"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-3352","authenticated-orcid":false,"given":"Bruno","family":"Ribeiro Baptista","sequence":"first","affiliation":[{"name":"D\u00e9partement de pneumologie CHRU de Nancy rue du Morvan 54500 Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Petitpain","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance CHRU de Nancy H\u00f4pital Central 29, avenue du Mar\u00e9chal de Lattre de Tassigny Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Gomez","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie CHRU de Nancy rue du Morvan 54500 Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Yeleh\u00e9\u2010Okouma","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance CHRU de Nancy H\u00f4pital Central 29, avenue du Mar\u00e9chal de Lattre de Tassigny Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Valentin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie CHRU de Nancy rue du Morvan 54500 Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Guillaumot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie CHRU de Nancy rue du Morvan 54500 Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Chabot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie CHRU de Nancy rue du Morvan 54500 Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Inserm U1116 Universit\u00e9 de Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Chaouat","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pneumologie CHRU de Nancy rue du Morvan 54500 Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Inserm U1116 Universit\u00e9 de Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00003313"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb10704.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584654"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900064"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.3_suppl.97S-a"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.9.2216"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.3_Supplement.200S"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.14.1400"},{"key":"e_1_2_7_11_1","first-page":"160","article-title":"Aminorex and pulmonary hypertension. 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