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Kleberg, Jr. and Helen C. Kleberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1HG006348"],"award-info":[{"award-number":["UM1HG006348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. In the current study, we report dystrophic cardiac calcinosis (<jats:styled-content style=\"fixed-case\">DCC<\/jats:styled-content>) in C.B\u201017<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content>male mice at 10 weeks of age with no significant change in cardiac function. Acquisition of<jats:styled-content style=\"fixed-case\">DCC<\/jats:styled-content>was characterized by myocardial injury, fibrosis, calcification, and necrosis of the tissue. At 10 weeks of age, 38% of the C.B\u201017<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content>mice from two different commercial colonies exhibited significant calcinosis on the ventricular epicardium, predominantly on the right ventricle. The frequency of calcinosis was more than 50% for mice obtained from Taconic's Cambridge City colony and 25% for mice obtained from Taconic's German Town colony. Interestingly, the<jats:styled-content style=\"fixed-case\">DCC<\/jats:styled-content>phenotype did not affect cardiac function at 10 weeks of age. No differences in echocardiography or electrocardiography were observed between the calcinotic and non\u2010calcinotic mice from either colony. Our findings suggest that C.B\u201017<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content>mice exhibit<jats:styled-content style=\"fixed-case\">DCC<\/jats:styled-content>as early as 10 weeks of age with no significant impact on cardiac function. This strain of mice should be cautiously considered for the study of cardiac physiology.<\/jats:p>","DOI":"10.1111\/fcp.12398","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T14:32:46Z","timestamp":1530369166000},"page":"25-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["C.B\u201017<scp>SCID<\/scp>mice develop epicardial calcinosis with unaltered cardiac function"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-9474","authenticated-orcid":false,"given":"Suchi","family":"Raghunathan","sequence":"first","affiliation":[{"name":"Department of Pharmacological and Pharmaceutical Sciences College of Pharmacy University of Houston Houston 77204 TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey L.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Mouse Phenotyping Core Baylor College of Medicine Houston 77030 TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Biology and Biochemistry University of Houston Houston 77204 TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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