{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:21:26Z","timestamp":1790385686800,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In contrast to statins, the risk of diabetes with fibrates was not clearly studied. This study investigates a putative signal of diabetes associated with the use of fibrates using the World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) global individual case safety reports database, VigiBase<jats:sup>\u00ae<\/jats:sup>. We included all reports registered until the 31st December 2017 in VigiBase<jats:sup>\u00ae<\/jats:sup> to measure the risk of reporting \u2018hyperglycemia or new onset of diabetes\u2019 (<jats:styled-content style=\"fixed-case\">SMQ<\/jats:styled-content> term) compared with all other reports [as a reporting odds ratio (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)] for fibrates, statins, and the combination fibrates\u00a0+\u00a0statins. The likelihood that diabetes resulted from statin\u2013fibrate interaction was also estimated. According to the interaction additive model, a <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> value for coexposure exceeding the sum of the <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>s estimated for each individual class of drug supports a potential drug\u2013drug interaction (<jats:styled-content style=\"fixed-case\">DDI<\/jats:styled-content>). To assess the stability of our results, we performed several sensitivity analyses, according to outcome definition and after exclusion of putative competitive (hyperglycemic) drugs. We included 19\u00a0149 patients exposed to fibrates (without statins), 177\u00a0323 to statins (without fibrates) and 3 247 to statins plus fibrates. In contrast to statins (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u00a0=\u00a01.75, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.72\u20131.78), no association was found for fibrates (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u00a0=\u00a00.76, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.71\u20130.82). The <jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> value was lower for the combination statins plus fibrates (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u00a0=\u00a01.46, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.28\u20131.67). Similar trends were found in sensitivity analyses. This study, performed in the real conditions of use, failed to find a signal of diabetes with fibrates. It strengths the association previously described with statin without any evidence for a statin\u2013fibrate <jats:styled-content style=\"fixed-case\">DDI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/fcp.12406","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T07:13:55Z","timestamp":1533971635000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk of diabetes with fibrates and statins: a pharmacoepidemiological study in VigiBase<sup>\u00ae<\/sup>"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-8126","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Montastruc","sequence":"first","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de PharmacoVigilance, Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament INSERM U 1027, CIC 1436 Centre Hospitalier Universitaire \u2013 Facult\u00e9 de M\u00e9decine Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-5336","authenticated-orcid":false,"given":"Justine","family":"Benevent","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de PharmacoVigilance, Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament INSERM U 1027, CIC 1436 Centre Hospitalier Universitaire \u2013 Facult\u00e9 de M\u00e9decine Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de PharmacoVigilance, Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament INSERM U 1027, CIC 1436 Centre Hospitalier Universitaire \u2013 Facult\u00e9 de M\u00e9decine Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3717-2784","authenticated-orcid":false,"given":"Genevi\u00e8ve","family":"Durrieu","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de PharmacoVigilance, Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament INSERM U 1027, CIC 1436 Centre Hospitalier Universitaire \u2013 Facult\u00e9 de M\u00e9decine Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Sommet","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de PharmacoVigilance, Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament INSERM U 1027, CIC 1436 Centre Hospitalier Universitaire \u2013 Facult\u00e9 de M\u00e9decine Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-6001","authenticated-orcid":false,"given":"Jean\u2010Louis","family":"Montastruc","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de PharmacoVigilance, Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament INSERM U 1027, CIC 1436 Centre Hospitalier Universitaire \u2013 Facult\u00e9 de M\u00e9decine Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61190-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.1096343"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2015.02.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-016-0795-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2007.00552.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04037.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2017.08.006"},{"key":"e_1_2_9_10_1","unstructured":"https:\/\/www.meddra.org\/standardised\u2010meddra\u2010queries. 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