{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:26:00Z","timestamp":1740126360965,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sulfuretin is a major flavonoid found in <jats:italic>Rhus verniciflua<\/jats:italic> and carries anti\u2010oxidative and anti\u2010inflammatory properties, but its potential use in the control of skin pigmentation is unknown. The purpose of the present study was to elucidate sulfuretin as a new active compound inhibiting melanogenesis and the underlying mechanism. The effects of sulfuretin on melanin production, tyrosinase activity, cAMP level, and MITF expression were examined in murine melanoma B16 cells challenged with forskolin or \u03b1\u2010MSH. The inhibitory effect of sulfuretin on melanogenesis was further validated on neonatal human melanocytes. When tested in melanoma B16 cells treated with forskolin or \u03b1\u2010MSH, sulfuretin inhibited the cellular melanogenesis. Sulfuretin also showed direct inhibitory effect on tyrosinase activity in vitro. In human primary melanocytes, the inhibitory effect of sulfuretin on melanin synthesis was also confirmed. Our current results support the depigmenting effect of sulfuretin and suggest a clinical strategy for using sulfuretin in the topical treatment of hyperpigmentation disorders.<\/jats:p>","DOI":"10.1111\/fcp.12414","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T07:38:40Z","timestamp":1537083520000},"page":"208-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of sulfuretin as a depigmenting agent"],"prefix":"10.1111","volume":"33","author":[{"given":"Zhike","family":"Zhou","sequence":"first","affiliation":[{"name":"Qingdao Municipal Hospital No. 21 Anhui Road Qingdao 266011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hou","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Hospital No. 21 Anhui Road Qingdao 266011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Xiong","sequence":"additional","affiliation":[{"name":"XiangYang Central Hospital Affiliated Hospital of Hubei College of Arts and Sciences XiangYang 441000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-0830","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Hospital No. 21 Anhui Road Qingdao 266011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.33376"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05660"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2000.130103.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-8703-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527636150.ch1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962013000100009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/edm.10.70"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2008.02.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071144"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00334.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.04.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.04.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.130236"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10094066"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-011-0515-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.202"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12084819"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2012.134"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2008.7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1954"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020633"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3130447"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500822"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf051258h"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.07.008"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19615.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2014.07.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14114425"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2015.16.2.135"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15058863"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00358.x"}],"container-title":["Fundamental &amp; 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