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Reports of pure agranulocytosis associated with a beta\u2010lactam exposure within the 10 days preceding the neutropaenia were extracted from the French Pharmacovigilance Database over the year 2010. Cases with another evident cause or more likely attributable to another drug were excluded. Data were analyzed for demographics, clinical and biological features, prognosis factors, granulocyte colony stimulating factors administration and outcome. Sixty\u2010two cases were included (median age: 65 years). The median duration of treatment before neutropaenia was 16 days. In 47% of cases, the diagnosis was made on a systematic blood cell count. The median neutrophil count at nadir was 0.125 \u00d7 10<jats:sup>9<\/jats:sup>\/L, and bone marrow examination evidenced features of neutrophilic maturation arrest or aplasia in 21 patients, hyperplasia of granulopoietic cells in three and normal findings in five. Three patients developed severe sepsis. All but one recovered a normal blood cell count within 2\u201356 days after beta\u2010lactam discontinuation. The last patient died from recurrent severe septic shock. No significant effect of granulocyte colony stimulating factor on the mean duration of haematological recovery was found. Among the 21 patients who later received another beta\u2010lactam, two experienced recurrence of the neutropaenia after receiving a beta\u2010lactam from another subfamily. Beta\u2010lactam\u2010induced agranulocytosis was usually observed after prolonged treatment, and severe complications are uncommon. In most patients, a subsequent treatment with another beta\u2010lactam was well tolerated.<\/jats:p>","DOI":"10.1111\/fcp.12419","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T07:58:59Z","timestamp":1538812739000},"page":"225-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Beta\u2010lactam\u2010induced severe neutropaenia: a descriptive study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3786-581X","authenticated-orcid":false,"given":"Thierry","family":"Vial","sequence":"first","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Hospices Civils de Lyon Service Hospitalo\u2010Universitaire de Pharmacotoxicologie  162 avenue Lacassagne Lyon 69424 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Bailly","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Hospices Civils de Lyon Service Hospitalo\u2010Universitaire de Pharmacotoxicologie  162 avenue Lacassagne Lyon 69424 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Christine","family":"Perault\u2010Pochat","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Centre Hospitalier R\u00e9gional et Universitaire  86021 Poitiers Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Default","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Marseille \u2010 Provence \u2010 Corse H\u00f4pital Sainte\u2010Marguerite AP\u2010HM  270 boulevard de Saint\u2010Marguerite 13274 Marseille Cedex 9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charl\u00e8ne","family":"Boulay","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Institut de Biologie Clinique H\u00f4pital Charles Nicolle CHU de Rouen  76031 Rouen cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Chouchana","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance H\u00f4pitaux Universitaires Paris Centre Site H\u00f4pital Cochin  27 rue du faubourg Saint Jacques 75014 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrouz","family":"Kassai","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Hospices Civils de Lyon Service Hospitalo\u2010Universitaire de Pharmacotoxicologie  162 avenue Lacassagne Lyon 69424 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the French Network of Pharmacovigilance Centres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1376645"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.869"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/archinte.1992.00400190095018","article-title":"Descriptive epidemiology of agranulocytosis","volume":"152","author":"Strom B.L.","year":"1992","journal-title":"Arch. 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