{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:24:50Z","timestamp":1790076290462,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunotherapy with immune checkpoint inhibitors (<jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content>s) for cancer has become increasingly prescribed in recent years. Indeed, it is used to treat both solid and hematological malignancies due to their considerable potential in treating melanoma, non\u2010small cell lung and other cancers. Immune\u2010mediated related adverse endocrine toxicity, and especially thyroiditis, is seen as a growing problem needing specific screening and management. This study aims at describing thyroid dysfunctions induced by the <jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content>s marketed in France, which are registered in the French Pharmacovigilance database. This database was queried for nivolumab, pembrolizumab, and ipilimumab\u2010induced adverse drug reactions reported before April 30, 2017. Both a pharmacologist and an endocrinologist have reviewed each case to select only those of peripheral thyroiditis (thyrotoxicosis and hypothyroidism). During this period, 110 thyroiditis following <jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content> therapy were reported. Sex\/ratio was around one. Most of the cases (47.2%) were asymptomatic. Although some thyrotoxicosis cases were severe, no orbitopathy was reported. Hypothyroidism and thyrotoxicosis were equally described. Antithyroid antibodies were positive in only 16% patients. The ultrasonography was informative in 19% patients. Levothyroxine supplementation was necessary in 57% patients, leading to 19% recovery. With a dedicated optimized management, most of the cases did not require immunotherapy discontinuation. Finally, immune\u2010mediated related thyroiditis is increasing due to a wider prescription of <jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content> therapy in various cancer conditions and systematic screening. Often asymptomatic, they lead to a local activation accompanied by hormonal deficiency in the long run. It is necessary to carry out an early and sustained multidisciplinary screening to allow immunotherapy continuation.<\/jats:p>","DOI":"10.1111\/fcp.12423","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T17:39:42Z","timestamp":1539279582000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Thyroiditis and immune check point inhibitors: the post\u2010marketing experience using the French National Pharmacovigilance database"],"prefix":"10.1111","volume":"33","author":[{"given":"Julie","family":"Garon\u2010Czmil","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance University Hospital of Nancy 29 avenue du Mar\u00e9chal de Lattre de Tassigny Nancy 54035 France"},{"name":"Department of Endocrinology and Medical Gynecology University Hospital of Nancy Rue du Morvan Vand\u0153uvre\u2010l\u00e8s\u2010Nancy 54500 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H\u00f4pital Henri Mondor Assistance Publique H\u00f4pitaux de Paris University Hospital of Creteil 51, avenue du Mar\u00e9chal de Lattre de Tassigny CRETEIL CEDEX 94010 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Yelehe\u2010Okouma","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance University Hospital of Nancy 29 avenue du Mar\u00e9chal de Lattre de Tassigny Nancy 54035 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Weryha","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Medical Gynecology University Hospital of Nancy Rue du Morvan Vand\u0153uvre\u2010l\u00e8s\u2010Nancy 54500 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Medical Gynecology University Hospital of Nancy Rue du Morvan Vand\u0153uvre\u2010l\u00e8s\u2010Nancy 54500 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-7508","authenticated-orcid":false,"given":"Pierre","family":"Gillet","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance University Hospital of Nancy 29 avenue du Mar\u00e9chal de Lattre de Tassigny Nancy 54035 France"},{"name":"UMR 7365 CNRS\u2010UL IMoPA Biop\u00f4le de l'Universit\u00e9 de Lorraine Campus Brabois\u2010Sant\u00e9 9 Avenue de la For\u00eat de Haye BP 20199 Vand\u0153uvre\u2010l\u00e8s\u2010Nancy 54505 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