{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:30:35Z","timestamp":1791851435532,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K19219"],"award-info":[{"award-number":["15K19219"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rhabdomyolysis is one of the most concerning complications of antidyslipidemic drugs. Most patients with dyslipidemia take multiple medications. Our objective was to explore which two\u2010drug combinations lead to a higher risk of rhabdomyolysis. We analyzed data from the Japanese Adverse Drug Event Report (<jats:styled-content style=\"fixed-case\">JADER<\/jats:styled-content>) database between April 2004 and September 2017. The primary outcome was the report of rhabdomyolysis. We assessed the risk of rhabdomyolysis for the two\u2010drug concomitant use of antidyslipidemic drugs (statin, fibrate, and ezetimibe) with antihypertensive and antidiabetic medications. The Nor\u00e9n and Gosho methods were used for detecting two\u2010drug interactions. The <jats:styled-content style=\"fixed-case\">JADER<\/jats:styled-content> contained 468\u00a0292 records for patient characteristics, 2\u00a0973\u00a0172 drug information records, and 741\u00a0016 adverse reactions records. Rhabdomyolysis was reported in 5\u00a0017 patients. Concomitant use of pravastatin\/fenofibrate, simvastatin\/mefruside, fluvastatin\/temocapril, bezafibrate\/temocapril, bezafibrate\/spironolactone, bezafibrate\/metoprolol, bezafibrate\/losartan, fluvastatin\/mitiglinide, or fenofibrate\/glibenclamide was detected as the signal of rhabdomyolysis in this analysis. Combination therapy with the drugs listed above has the potential of drug\u2013drug interactions that could result in rhabdomyolysis in patients with dyslipidemia.<\/jats:p>","DOI":"10.1111\/fcp.12435","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T12:05:34Z","timestamp":1545393934000},"page":"339-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rhabdomyolysis risk from the use of two\u2010drug combination of antidyslipidemic drugs with antihypertensive and antidiabetic medications: a signal detection analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-9163","authenticated-orcid":false,"given":"Masahiko","family":"Gosho","sequence":"first","affiliation":[{"name":"Department of Biostatistics Faculty of Medicine University of Tsukuba 1\u20101\u20101 Tennodai Tsukuba Ibaraki 305\u20108575 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"CD004816","article-title":"Statins for the primary prevention of cardiovascular disease","volume":"1","author":"Taylor F.","year":"2011","journal-title":"Cochrane Database Syst. 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