{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:01:46Z","timestamp":1772550106957,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypoxic pulmonary vasoconstriction (HPV) is a protective mechanism maintaining blood oxygenation by redirecting blood flow from poorly ventilated to well\u2010ventilated areas in the lung. Such a beneficial effect is blunted by antihypertensive treatment with dihydropyridine calcium channel inhibitors. The aim of the present study was to evaluate the effect of urapidil, an antihypertensive agent acting as an \u03b1<jats:sub>1<\/jats:sub> adrenergic antagonist and a partial 5\u2010HT<jats:sub>1A<\/jats:sub> agonist, on HPV in porcine proximal and distal pulmonary artery rings, and to characterize underlying mechanisms. Rings from proximal and distal porcine pulmonary artery were suspended in organ chambers and aerated with a 95% O<jats:sub>2<\/jats:sub> + 5% CO<jats:sub>2<\/jats:sub> gas mixture. HPV was induced by changing the gas to a 95% N<jats:sub>2<\/jats:sub> + 5% CO<jats:sub>2<\/jats:sub> mixture following a low level of pre\u2010contraction with U46619. Hypoxia induced a contractile response in both proximal and distal pulmonary artery rings. This effect is observed in the presence of a functional endothelium and is inhibited by a soluble guanylyl cyclase inhibitor (ODQ), a NO scavenger (carboxy\u2010PTIO), and by catalase in proximal pulmonary artery rings. The endothelium\u2010dependent HPV is prevented by nicardipine and clevidipine but remained unaffected by urapidil in both proximal and distal pulmonary artery rings. These findings indicate that urapidil, in contrast to nicardipine and clevidipine, preserves the hypoxia\u2010triggered vasoconstriction in isolated pulmonary arteries. They further indicate the involvement of the NO\u2010guanylyl cyclase pathway and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in HPV. Further research is warranted to determine the potential clinical relevance of the preserved hypoxia\u2010induced pulmonary vasoconstriction by urapidil.<\/jats:p>","DOI":"10.1111\/fcp.12457","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T18:40:47Z","timestamp":1551292847000},"page":"527-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Urapidil, but not dihydropyridine calcium channel inhibitors, preserves the hypoxic pulmonary vasoconstriction: an experimental study in pig arteries"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3621-1494","authenticated-orcid":false,"given":"Claire","family":"Bopp","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy UMR CNRS 7213 University of Strasbourg  Illkirch France"},{"name":"Department of Anesthesia and Critical Care Hautepierre University Hospitals  Avenue Moli\u00e8re Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Auger","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy UMR CNRS 7213 University of Strasbourg  Illkirch France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Burn and Critical Care Saint Louis and Lariboisi\u00e8re University Hospitals UMRS\u2010942 INSERM University Paris Diderot  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish P.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Management University of Texas Southwestern Medical School  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie B.","family":"Schini\u2010Kerth","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy UMR CNRS 7213 University of Strasbourg  Illkirch France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Diemunsch","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care Hautepierre University Hospitals  Avenue Moli\u00e8re Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000569"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneumo.2011.08.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.5.L856"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045-8932.114776"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00448.2004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00319.2003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2002.92.2.527"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014519"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-1022-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.12.023"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199711000-00008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2004.tb00143.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198703000-00010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90187-D"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.03.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90819-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.1992.tb00373.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199000404-00003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198409000-00008"},{"key":"e_1_2_6_22_1","first-page":"1119","article-title":"Hypoxic pulmonary vasoconstriction: redox regulation of O2\u2010sensitive K+ channels by a mitochondrial O2\u2010sensor in resistance artery smooth muscle cells","volume":"37","author":"Michelakis E.D.","year":"2004","journal-title":"J. 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