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A rat hepatic injury model of chronic aluminum injury was established by the intragastric administration of aluminum gluconate (Al3\u00a0+\u00a0200\u00a0mg\/kg per day, 5\u00a0days a week for 20\u00a0weeks). The <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 inhibitor [meloxicam (1\u00a0mg\/kg)] and 5\u2010<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> inhibitor [caffeic acid (30\u00a0mg\/kg)] were intragastrically administered 1\u00a0h after aluminum administration. The histopathology was detected by hematoxylin\u2010eosin staining. A series of biochemical indicators were measured with biochemistry assay or <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>s. The expressions of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 and 5\u2010<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> were measured by immunohistochemistry. Our experimental results showed that aluminum overload caused a significant damage to the liver and also significantly increased the expressions of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102, 5\u2010<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> and the levels of inflammation and oxidative stress. The administration of meloxicam and caffeic acid significantly protected livers against histopathological injury, significantly decreased plasma <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AST<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content> levels, significantly decreased <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 levels, and oxidative stress. However, the administration of caffeic acid did not significantly increase the expression of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 compared with the model group. On the other hand, the administration of meloxicam also did not significantly increase the expression of 5\u2010<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> compared with the model group. Our results indicate that there is no compensation between <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 pathway and 5\u2010<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> pathway by inhibiting either <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 or 5\u2010<jats:styled-content style=\"fixed-case\">LOX<\/jats:styled-content> in chronic aluminum overload\u2010induced liver injury rat.<\/jats:p>","DOI":"10.1111\/fcp.12465","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T13:49:51Z","timestamp":1553348991000},"page":"535-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment with either <scp>COX<\/scp>\u20102 inhibitor or 5\u2010<scp>LOX<\/scp> inhibitor causes no compensation between <scp>COX<\/scp>\u20102 pathway and 5\u2010<scp>LOX<\/scp> pathway in chronic aluminum overload\u2010induced liver injury in rats"],"prefix":"10.1111","volume":"33","author":[{"given":"Hui","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Pharmacology Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University Chongqing 400016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University Chongqing 400016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neonatalogy Children's 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