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This current study aims to determine the possible neuroprotective effects of zafirlukast, piracetam and the combination of piracetam and zafirlukast on L\u2010methionine\u2010induced vascular dementia in rats. Male Wistar albino rats were divided into five groups. Group I was the normal control, and group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> received L\u2010methionine (1700\u00a0mg\/kg, P.O.) for 32\u00a0days. The remaining groups received zafirlukast (20\u00a0mg\/kg, P.O.), piracetam (600\u00a0mg\/kg, P.O.) or their combination (zafirlukast 20\u00a0mg\/kg\u00a0+\u00a0piracetam 600\u00a0mg\/kg, P.O.) for 32\u00a0days after L\u2010methionine administration. Afterwards, the cognitive and memory performances of the rats were investigated using the novel object recognition (<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content>) test; rats were then sacrificed for histopathological and biochemical analyses. L\u2010methionine\u2010induced vascular dementia altered rats\u2019 behaviours and the brain contents of different neurotransmitters and acetylcholinesterase activity while increasing levels of oxidative stress and causing notable histopathological alterations in brain tissues. The treatment of vascular dementia with zafirlukast and the combination improved neurochemical, behavioural and histological alterations to a comparable level to those of piracetam. Thus, zafirlukast, piracetam and the combination of both drugs can be considered as potential therapeutic strategies for the treatment of vascular dementia induced by L\u2010methionine. To the best of our knowledge, this study is the first to explore the neuroprotective effects of zafirlukast and piracetam on L\u2010methionine\u2010induced vascular dementia.<\/jats:p>","DOI":"10.1111\/fcp.12473","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T05:34:22Z","timestamp":1555652062000},"page":"634-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neuroprotective effects of zafirlukast, piracetam and their combination on L\u2010Methionine\u2010induced vascular dementia in rats"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-0653","authenticated-orcid":false,"given":"Ahmed M.","family":"Fayez","sequence":"first","affiliation":[{"name":"Pharmacology Department October University for Modern Science and Arts 11787 6 October City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-1326","authenticated-orcid":false,"given":"Ahmed S.","family":"Elnoby","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department Children's Cancer Hospital Egypt 57357 Cairo Egypt"},{"name":"Faculty of Pharmacy October University for Modern Science and Arts 11787 6 October City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada H.","family":"Bahnasawy","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy October University for Modern Science and Arts 11787 6 October City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-4830","authenticated-orcid":false,"given":"Omar","family":"Hassan","sequence":"additional","affiliation":[{"name":"Pharmacology Department October University for Modern Science and Arts 11787 6 October City Egypt"},{"name":"Faculty of Pharmacy October University for Modern Science and Arts 11787 6 October City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.210"},{"key":"e_1_2_6_3_1","first-page":"16310","article-title":"Mild cognitive impairment in adult: a neuropsychological review","volume":"16","author":"Yanhong O.","year":"2013","journal-title":"Ann. 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