{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:56:08Z","timestamp":1768982168589,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>When intramuscular or intravenous administrations of parenteral drugs are not possible, the use of other routes (e.g., subcutaneous route) should be considered. We report a patient with Duchenne muscular dystrophy, who was hospitalized for acute pneumonia due to antibiotic\u2010resistant strains of bacteria. Our patient was successfully recovered with antimicrobial therapy by subcutaneous administration of ceftazidime and tobramycin, for which no safety and efficacy data are available in humans. To the best of our knowledge, this case is the first supporting the subcutaneous administration safety and potential efficacy of both ceftazidime and tobramycin in humans.<\/jats:p>","DOI":"10.1111\/fcp.12477","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T03:09:39Z","timestamp":1556680179000},"page":"703-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A successful antibiotic treatment by a new administration route: a case report of a subcutaneous administration of ceftazidime and tobramycin"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1549-2170","authenticated-orcid":false,"given":"Doroth\u00e9e","family":"Duron","sequence":"first","affiliation":[{"name":"P\u00f4le Pharmacie Centre Hospitalier Universitaire Grenoble Alpes Grenoble 38000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Chanoine","sequence":"additional","affiliation":[{"name":"P\u00f4le Pharmacie Centre Hospitalier Universitaire Grenoble Alpes Grenoble 38000 France"},{"name":"Universit\u00e9 Grenoble Alpes Grenoble 38000 France"},{"name":"CR UGA\/Inserm 1209\/CNRS UMR 5309 Institute for Advanced Biosciences Grenoble 38000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud","family":"Peron","sequence":"additional","affiliation":[{"name":"P\u00f4le Pharmacie Centre Hospitalier Universitaire Grenoble Alpes Grenoble 38000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Lepelley","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance Grenoble 38000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beno\u00eet","family":"Allenet","sequence":"additional","affiliation":[{"name":"P\u00f4le Pharmacie Centre Hospitalier Universitaire Grenoble Alpes Grenoble 38000 France"},{"name":"Universit\u00e9 Grenoble Alpes Grenoble 38000 France"},{"name":"TIMC\u2010IMAG UMR 5525\/ThEMAS CNRS Grenoble 38000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Epaulard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes Grenoble 38000 France"},{"name":"Clinique Universitaire des Maladies infectieuses et tropicales Centre Hospitalier Universitaire Grenoble Alpes Grenoble 38000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boubou","family":"Camara","sequence":"additional","affiliation":[{"name":"Service Hospitalier Universitaire de Pneumologie\u2010Physiologie P\u00f4le Thorax et Vaisseaux Centre Hospitalier Universitaire Grenoble Alpes Grenoble 38000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierrick","family":"Bedouch","sequence":"additional","affiliation":[{"name":"P\u00f4le Pharmacie Centre Hospitalier Universitaire Grenoble Alpes Grenoble 38000 France"},{"name":"Universit\u00e9 Grenoble Alpes Grenoble 38000 France"},{"name":"TIMC\u2010IMAG UMR 5525\/ThEMAS CNRS Grenoble 38000 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.03967.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2014.11.017"},{"key":"e_1_2_10_4_1","first-page":"151","article-title":"Tolerance of subcutaneously administered antibiotics: a French national prospective study","volume":"46","author":"Roubaud\u2010Baudron C.","year":"2017","journal-title":"Age Ageing"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2008.07.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.1.13"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2009.01104.x"},{"key":"e_1_2_10_8_1","first-page":"7","article-title":"Absorption kinetics of subcutaneously administered ceftazidime in hypoperfused guinea pigs","volume":"18","author":"Ebihara T.","year":"2014","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04627-14"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(91)90069-Z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2014.09.601"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060515625431"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffcp.12477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:37:18Z","timestamp":1694212638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,24]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/fcp.12477"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12477","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,24]]},"assertion":[{"value":"2019-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}