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This molecule has various pharmacological properties including improving immune system, prevent cancer, anti\u2010aging, and anti\u2010oxidant effects. The anticonvulsant effects of melatonin have been proved by previous studies. Adenosine triphosphate (ATP)\u2010sensitive potassium (K<jats:sub>ATP<\/jats:sub>) channels are considered as an important target in the seizure modulation. The aim of the present study was to investigate the anticonvulsant effect of melatonin in pentylenetetrazole (PTZ)\u2010induced seizures in mice, focusing on its ability to regulate K<jats:sub>ATP<\/jats:sub> channels. Acute intraperitoneal administration of melatonin (40 and 80\u00a0mg\/kg) increased clonic seizure threshold induced by intravenous administration of PTZ. Melatonin (40 and 80\u00a0mg\/kg) increased the latency of clonic seizure and reduced its frequency in mice receiving an intraperitoneal injection of PTZ. Administration of glibenclamide, a K<jats:sub>ATP<\/jats:sub> channels blocker, before intravenous injection of PTZ reduced melatonin anticonvulsant effect. Diazoxide and cromakalim, as K<jats:sub>ATP<\/jats:sub> channels openers, increased antiseizure effect of melatonin in PTZ model of seizures. These findings suggest that the antiseizure effect of melatonin probably is gained through increasing the opening of K<jats:sub>ATP<\/jats:sub> channels.<\/jats:p>","DOI":"10.1111\/fcp.12490","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T07:13:00Z","timestamp":1560496380000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Anticonvulsant effect of melatonin through ATP\u2010sensitive channels in mice"],"prefix":"10.1111","volume":"34","author":[{"given":"Fatemeh","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Brain and Spinal Cord Injury Research Center Neuroscience Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Shakiba","sequence":"additional","affiliation":[{"name":"Brain and Spinal Cord Injury Research Center Neuroscience Institute Tehran 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