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The aim of this study was to reveal whether therapeutic value of cannabinoid 2 (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>2) receptor activity in the intestinal I\/R, via to the exogenous administration of <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>2 agonist (<jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u20101241). Intestinal I\/R injury were performed through 30\u2010min ischemia and 150\u2010min reperfusion of mesenteric artery in Wistar rats. The pre\u2010administered doses of 0.1, 1, and 5\u00a0mg\/kg of <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>2 agonist were studied to inhibit inflammation of intestinal I\/R injury including ileum smooth muscle contractility, polymorphonuclear cell migration, oxidant\/antioxidant defense system, and provocative cytokines. Pre\u2010administration with <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>2 receptor agonist ensured to consider improving the disrupted contractile responses in ileum smooth muscle along with decreased the formation of <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> that production of lipid peroxidation, reversed the depleted glutathione, inhibited the expression of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 in the intestinal I\/R of rats. Taken together results of this research, the agonistic activity of <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>2 receptor for healing of intestinal I\/R injury is ensuring associated with anti\u2010inflammatory mechanisms such as the inhibiting of migration of inflammatory polymorphonuclear cells that origin of acute and initial responses of inflammation, the inhibiting of production of provocative and pro\u2010inflammatory cytokines like <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, the rebalancing of oxidant\/antioxidant redox system disrupted in injury of reperfusion period and the supporting of physiologic defensive systems in endothelial and inducible inflammatory 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