{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:49:47Z","timestamp":1788997787248,"version":"build-2803163510"},"reference-count":119,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901993"],"award-info":[{"award-number":["30901993"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973003"],"award-info":[{"award-number":["30973003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prostate cancer and prostatitis are both significant health concerns. A large number of studies have established that the occurrence of the two is closely related. However, the most common prostatitis, type III chronic prostatitis\/chronic pelvic pain syndromes (CP\/CPPS), is reported to not correlate with the occurrence of prostate cancer. Although the etiology of CP\/CPPS is unknown, it may be related to the autoimmune mechanism favored by most studies. Manipulating the immune system and targeting tumor microenvironment are promising new methods for the treatment of prostate cancer. Therefore, this review focuses on the immune cells and cytokines of CP\/CPPS and prostate cancer from the perspective of biological immunology and immune microenvironment. We discuss T\u2010regulatory (Treg) and T helper 17 (Th17) cells dysfunction, the abnormal regulation of T helper 1(Th1) and T helper 2 (Th2) cells, macrophages, and their related cytokines as key activators in CP\/CPPS. In addition, we discuss the roles of Treg and Th17 cells, Th1 and Th2 cells, and related cytokines in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines provide a research strategy for the etiology of CP\/CPPS and offer potentially promising targets for the treatment of prostate cancer.<\/jats:p>","DOI":"10.1111\/fcp.12517","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T05:25:28Z","timestamp":1571808328000},"page":"160-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Chronic prostatitis\/chronic pelvic pain syndrome and prostate cancer: study of immune cells and cytokines"],"prefix":"10.1111","volume":"34","author":[{"given":"Yuqian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-4619","authenticated-orcid":false,"given":"Reyaj","family":"Mikrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianyou","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junaid","family":"Wazir","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajan","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahat","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza Muhammad Faran Ashraf","family":"Baig","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Sciences School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar","family":"Ahmed","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai Jiao Tong University Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek Kumar","family":"Srivastava","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai Jiao Tong University Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedar Bahadur","family":"Thapa","sequence":"additional","affiliation":[{"name":"Institute of Advanced Materials Nanjing Tech University Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-4497","authenticated-orcid":false,"given":"Xiaohui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Nanjing Jiangsu 211198 China"},{"name":"Department of Surgery Zhongda Hospital Affiliated to Southeast University Nanjing Jiangsu 210017 China"},{"name":"Department of Surgery Nanjing Shuiximen Hospital Nanjing Jiangsu 210017 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00240.2012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.055"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.167"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04033.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000101022.38330.7c"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a000783"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.63"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01853.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.10.020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2259"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8346-y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-017-0198-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060987"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21327"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12922"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.031"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3603-8_19"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.105"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm014"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/794968"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0391-3"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80089-1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.11.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.07.1229"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33097"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202482"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21410"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101212"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028648"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-006-0002-6"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000405"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00972.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1551"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20916"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125623"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890802068582"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1559"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2002.5281"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8504"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-200403000-00007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.03.011"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.07.067"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00898"},{"key":"e_1_2_7_47_1","first-page":"330","article-title":"Detection of peripheral blood Th1\/Th2 cell ratio in patients with chronic abacterial prostatitis\/chronic pelvic pain syndrome","volume":"12","author":"Liu H.\u2010H.","year":"2006","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.09.37"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64916-6"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.06.028"},{"key":"e_1_2_7_51_1","first-page":"63","article-title":"Expression of macrophage inflammatory protein\u20101alpha in EPS and its significance","volume":"18","author":"Zou W.","year":"2012","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.01.028"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.06.033"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.02.019"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.3109\/21681805.2013.769460"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00013.2018"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02528.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23194"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00563"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-5164"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23343"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24497"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7398"},{"key":"e_1_2_7_64_1","first-page":"420","article-title":"Changes of CD4 + CD25 + Foxp3 + regulatory T cells in the peripheral blood and their correlation with insulin resistance in different stages of prostate cancer","volume":"21","author":"Zhang B.W.","year":"2015","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.11.035"},{"key":"e_1_2_7_66_1","first-page":"1003","article-title":"Increased peripheral CD4+CD25high Treg in prostate cancer patients is correlated with PSA","volume":"32","author":"Akin Y.","year":"2011","journal-title":"Saudi Med. J."},{"key":"e_1_2_7_67_1","first-page":"888","article-title":"Expressions of CD4+ CD25(high) regulatory T cells, TGF\u2010beta 1 and COX\u20102 in the peripheral blood of prostate cancer patients","volume":"17","author":"Xia T.L.","year":"2011","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-014-1591-2"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02604.x"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.164"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28026"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2013.22"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-2056"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-005-0110-x"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0688-7"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0842"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.11.083"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2429"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4804-9"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23442"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.4.532"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.1066"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5467"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0010"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20000901)44:4<271::AID-PROS2>3.0.CO;2-G"},{"key":"e_1_2_7_87_1","first-page":"25586","article-title":"Concurrent, but not sequential, PD\u20101 blockade with a DNA vaccine elicits anti\u2010tumor responses in patients with metastatic, castration\u2010resistant prostate cancer","volume":"9","author":"McNeel D.G.","year":"2018","journal-title":"Oncoimmunology"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2015.03.004"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1159\/000030039"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2039"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12377"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7248"},{"issue":"1","key":"e_1_2_7_93_1","first-page":"21","article-title":"Performance of abiraterone and enzalutamide in metastatic castration\u2010resistant prostate cancer men: a head to head comparison based on a 2014\u20132017 French population\u2010based study","volume":"33","author":"Scailteux L.M.","year":"2019","journal-title":"Fundam. Clin. Pharmacol."},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.04.019"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01030-0"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.08.093"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.770"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/359693a0"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20001001)45:2<167::AID-PROS11>3.0.CO;2-J"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.2909"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1257"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.024"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1051"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15651"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12357"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62092-5"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200009010-00024"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri774"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20000615)44:1<49::AID-PROS7>3.0.CO;2-7"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21271"},{"key":"e_1_2_7_113_1","first-page":"3760","article-title":"Trp\u2010p8, a novel prostate\u2010specific gene, is upregulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins","volume":"61","author":"Tsavaler L.","year":"2001","journal-title":"Can. Res."},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.004"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12438"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-00968-5"},{"key":"e_1_2_7_117_1","first-page":"4129","article-title":"RNA interference\u2010mediated depletion of TRPM8 enhances the efficacy of epirubicin chemotherapy in prostate cancer LNCaP and PC3 cells","volume":"15","author":"Liu T.","year":"2018","journal-title":"Oncol. Lett."},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2146"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051825"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2146"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:39:28Z","timestamp":1694011168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":119,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/fcp.12517"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12517","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"assertion":[{"value":"2019-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}