{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:14:18Z","timestamp":1780938858602,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Buprenorphine is a \u00b5\u2010partial agonist and k\u2010antagonist acting on central opioid receptors. Patented for analgesia in 1968, buprenorphine has been used as opioid substitutive therapy since the 1990s, as well as methadone. The aim was to document pediatric poisoning, to discover the severity, and to evaluate the treatment with naloxone. All pediatric poisonings reported to the poison control center Marseille (France)\u2014from January 1, 2009 to December 31, 2018\u2014were included. Analysis put value on gender, age, estimated quantity, symptoms and their delay, place of treatment, medical treatment, utilization of antidotes, severity of intoxications, and patients\u2019 outcome. Fifty\u2010four infant poisonings with buprenorphine were recorded, doses varied between 1 and 36\u00a0mg, and children showed mainly neurological (somnolence, miosis\u2026) and gastroenteric (vomiting) effects. Pulmonary effects were described for four children. According to the poisoning severity score, 8 intoxications were classified as \u2018no symptoms or signs\u2019, 37 as minor poisonings, 3 as moderate, none as severe or fatal and 6 were unknown. Medical care was required for 46 children, and four of them were treated with naloxone. Buprenorphine poisoning can cause neurological, gastroenteric, and respiratory symptoms. Even licking a tablet leads to intoxication because of maximal tablet\u2019s absorption while placing it under the tongue. Hospital admission is necessary even at small doses. Naloxone was efficient in the four described cases. Parents have to be aware of the poisoning risk with buprenorphine. Recently, commercialized instantly dissolving formulations could cause more severe intoxications.<\/jats:p>","DOI":"10.1111\/fcp.12518","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T20:43:54Z","timestamp":1572641034000},"page":"265-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Buprenorphine poisoning in children: a 10\u2010year\u2010experience of Marseille Poison Center"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-027X","authenticated-orcid":false,"given":"Katharina","family":"von Fabeck","sequence":"first","affiliation":[{"name":"Service de Pharmacologie Clinique, CAP-TV H\u00f4pital Sainte Marguerite APHM Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Boulamery","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique, CAP-TV H\u00f4pital Sainte Marguerite APHM Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Glaizal","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique, CAP-TV H\u00f4pital Sainte Marguerite APHM Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"de Haro","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique, CAP-TV H\u00f4pital Sainte Marguerite APHM Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Simon","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique, CAP-TV H\u00f4pital Sainte Marguerite APHM Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael051"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.10.047"},{"key":"e_1_2_7_4_1","volume-title":"Emergency department visits involving the accidental ingestion of opioid pain relievers by children aged 1 to 5. The CBHSQ Report","author":"Crane E.H.","year":"2013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2017.01.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181f3a118"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1774"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-4232"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-3652"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200607000-00012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.01.006"},{"key":"e_1_2_7_12_1","first-page":"819","article-title":"Child poisonings with methadone in France: A 6\u2010year prospective national survey since the availability of capsules in 2008","volume":"53","author":"Torrents R.","year":"2015","journal-title":"Clin. Toxicol. (Phila)"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffcp.12518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T18:38:46Z","timestamp":1694025526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,28]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/fcp.12518"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12518","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,28]]},"assertion":[{"value":"2019-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}