{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:08:50Z","timestamp":1758632930072,"version":"3.40.5"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preconditioning is a well\u2010documented strategy that induces hepatic protection, renal protection, cardioprotection, and neuroprotection but its mechanism still remains to be elucidated. Hence, the present study investigated the protective mechanism underlying pain attenuating effects of vincristine\u2010preconditioning in chemotherapeutic agent\u2010induced neuropathic pain. Neuropathic pain was induced by administration of vincristine (50\u00a0\u00b5g\/kg, i.p.) for 10\u00a0days in rats. Vincristine\u2010preconditioning was induced by administration of vincristine (2, 5, and 10\u00a0\u00b5g\/kg, i.p) for 5\u00a0days before administration of pain\u2010inducing dose of vincristine (50\u00a0\u00b5g\/kg, i.p.). Vincristine\u2010preconditioning (10\u00a0\u00b5g\/kg, i.p) for 5\u00a0days significantly reduced vincristine (50\u00a0\u00b5g\/kg, i.p.) induced pain\u2010related behaviors including paw cold allodynia, mechanical hyperalgesia, and heat hyperalgesia. However, vincristine (2 and 5\u00a0\u00b5g\/kg, i.p) did not significantly ameliorate the vincristine (50\u00a0\u00b5g\/kg, i.p.) induced neuropathic pain in rats. Furthermore, to explore the involvement of calcium channels in pain attenuating mechanism of vincristine\u2010preconditioning, T\u2010type calcium channel blocker, ethosuximide (100 and 200\u00a0mg\/kg, i.p.) and L\u2010type calcium channel blocker, amlodipine (5 and 10\u00a0mg\/kg, i.p.) were used. Pretreatment with T\u2010type calcium channel blocker, ethosuximide significantly abolished vincristine\u2010preconditioning\u2010induced protective effect. However, pretreatment with L\u2010type calcium channel blocker, amlodipine did not alter vincristine\u2010preconditioning\u2010induced pain\u2010related behaviors. This indicates that vincristine\u2010preconditioning has protective effect on pain\u2010related parameters due to opening of calcium channels, particularly T\u2010type calcium channels that lead to entry of small magnitude of intracellular calcium through these channels and prevent the deleterious effects of high\u2010dose vincristine.<\/jats:p>","DOI":"10.1111\/fcp.12519","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T16:59:59Z","timestamp":1572973199000},"page":"336-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pain attenuating actions of vincristinet\u2010preconditioning in chemotherapeutic agent\u2010induced neuropathic pain: key involvement of T\u2010type calcium channels"],"prefix":"10.1111","volume":"34","author":[{"given":"Jasmine","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Drug Research Punjabi University Patiala 147002 Patiala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid N.","family":"Maslov","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology Institute of Cardiology Kyevskaya 111 634012 Tomsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-5284","authenticated-orcid":false,"given":"Nirmal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Drug Research Punjabi University Patiala 147002 Patiala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amteshwar Singh","family":"Jaggi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Drug Research Punjabi University Patiala 147002 Patiala India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2017.09.002"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Perspectives of pain in patients with type 2 diabetes","volume":"19","author":"Kirk J.K.","year":"2019","journal-title":"Expert Rev. 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