{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:51:30Z","timestamp":1784742690297,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ischemic heart disease is a common cardiac health problem. Despite the significant advances in prevention and treatment of this disorder, its incidences and complications are very serious. So, the search for more antioxidants and anti\u2010inflammatory agents with cardioprotective effects is an urgent task. We aimed to evaluate the effects of a heme oxygenase 1 (HO1) inducer, hemin (HEM), on isoprenaline (ISO)\u2010induced myocardial damage. Forty\u2010five Wistar albino rats were used. Animals were treated with HEM (25\u00a0mg\/kg\/day) <jats:italic>i.p<\/jats:italic>. for 5\u00a0days and injected with ISO (150\u00a0mg\/kg\/day) <jats:italic>i.p<\/jats:italic>. on 4th and 5th day of the experiment. Detection of the role of ATP\u2010sensitive potassium channel (K<jats:sub>ATP<\/jats:sub>) was performed by administration of glibenclamide (GP) (5\u00a0mg\/kg\/day) orally 2\u00a0h before HEM. Moreover, the role of endothelial nitric oxide synthase (eNOS) was detected by coadministration of Nitro\u2010 \u03c9\u2010L\u2010arginine (L\u2010NNA) (25\u00a0mg\/kg\/day) for 5\u00a0days. The ISO group showed increase in heart weight, cardiac enzymes, tumor necrosis factor alpha (TNF\u03b1), and malondialdehyde (MDA) with decrease in reduced glutathione (GSH), HO1, and total antioxidant capacity (TAC). In addition, there were increases in Bcl\u20102 associated X protein (Bax) and cleaved caspase\u20103, but decreases in B\u2010cell lymphoma\u20102 (Bcl\u20102) and eNOS. Moreover, the histopathological examination of\u00a0the ISO group showed degeneration of the cardiac muscle fibers and marked infiltration of the inflammatory cells. The biochemical and histopathological changes induced by ISO were markedly ameliorated in the HEM plus ISO group. This protective effect was diminished with coadministration of GP or L\u2010NNA; thus, K<jats:sub>ATP<\/jats:sub> and eNOS might mediate HEM cardioprotection.<\/jats:p>","DOI":"10.1111\/fcp.12529","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T09:11:48Z","timestamp":1576746708000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cardioprotective effect of hemin in isoprenaline\u2010induced myocardial infarction: role of ATP\u2010sensitive potassium channel and endothelial nitric oxide synthase"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-9558","authenticated-orcid":false,"given":"Marwa M.M.","family":"Refaie","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Minia University 61511 El\u2010Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab A.","family":"Rifaai","sequence":"additional","affiliation":[{"name":"Department of Histology and cell biology Faculty of Medicine Minia University 61511 El\u2010Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa M.A.","family":"Bayoumi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Minia University 61511 El\u2010Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed","family":"Shehata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Minia University 61511 El\u2010Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9302414"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Protective effects of olive leaf extract on acrolein\u2010exacerbated myocardial infarction via an endoplasmic reticulum stress pathway","volume":"19","author":"Xu Y.","year":"2018","journal-title":"Int. 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