{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:54:00Z","timestamp":1787882040445,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hearing loss is defined as a decrease in the ability to perceive sounds which can occur suddenly or gradually and affects one ear or both. It is related to various etiologies, in particular drugs. The identification of all drugs that could be associated with hearing loss is essential for the patients' life quality. The objective of our study was to identify signals of hearing loss involving drugs approved in the last 20\u00a0years. The occurrence in association with drugs known for their ototoxicity was also analyzed. We used a case\/non\u2010case method in the French Pharmacovigilance Database (FPVD). The cases were reports of hearing loss in the FPVD between January 2007 and August 2017. Non\u2010cases were all reports over the same period. We calculated the reporting odds ratio (ROR) with 95% confidence intervals. Among the 555 reports of hearing loss, significant RORs were found for 68 drugs. The main therapeutic classes implicated were antineoplastic agents (<jats:italic>n<\/jats:italic>\u00a0=\u00a0240), systemic anti\u2010infective agents (<jats:italic>n<\/jats:italic>\u00a0=\u00a0182), immunosuppressants (<jats:italic>n<\/jats:italic>\u00a0=\u00a042) loop diuretics (<jats:italic>n<\/jats:italic>\u00a0=\u00a026), and salicylate analgesics (<jats:italic>n<\/jats:italic>\u00a0=\u00a026). We found signals of hearing loss with azacitidine, vaccines and nevirapine, immunosuppressants such as leflunomide, and biotherapies such as panitumumab and vandetanib. Prescribers should be informed about the potential associations with all these drugs. The role of the pathology itself and the known ototoxic drugs that can be associated do not allow to conclude definitively. Audiograms for the early detection of hearing loss induced by drugs known to be ototoxic are rarely carried out. Preventive treatments exist and must be considered.<\/jats:p>","DOI":"10.1111\/fcp.12533","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T10:46:25Z","timestamp":1578480385000},"page":"397-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Drug\u2010induced hearing loss: a case\/non\u2010case study in the French pharmacovigilance database"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-545X","authenticated-orcid":false,"given":"Sylvie","family":"Favreli\u00e8re","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance University Hospital of Poitiers 2 rue de la Mil\u00e8trie, BP 577 86021 Poitiers Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Delaunay","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance University Hospital of Poitiers 2 rue de la Mil\u00e8trie, BP 577 86021 Poitiers Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pascal","family":"Lebreton","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery University Hospital of Poitiers 2, rue de la Mil\u00e8trie, BP 577 86021 Poitiers Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Rouby","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance University Hospital of Marseille 270 Boulevard Sainte Marguerite 13009 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Atzenhoffer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance Hospices civils de Lyon 69424 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lafay\u2010Chebassier","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance University Hospital of Poitiers 2 rue de la Mil\u00e8trie, BP 577 86021 Poitiers Cedex France"},{"name":"INSERM, U1084 Laboratoire de Neurosciences Exp\u00e9rimentales et Cliniques \u2013 LNEC Universit\u00e9 de Poitiers Batiment B36, 1 rue Georges Bonnet, BP633 86022 Poitiers Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Christine","family":"P\u00e9rault\u2010Pochat","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacovigilance University Hospital of Poitiers 2 rue de la Mil\u00e8trie, BP 577 86021 Poitiers Cedex France"},{"name":"INSERM, U1084 Laboratoire de Neurosciences Exp\u00e9rimentales et Cliniques \u2013 LNEC Universit\u00e9 de Poitiers Batiment B36, 1 rue Georges Bonnet, BP633 86022 Poitiers Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"290","article-title":"Drug Induced hearing loss","volume":"23","year":"2014","journal-title":"Prescrire Int."},{"key":"e_1_2_6_3_1","first-page":"601","article-title":"Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus : a reasoned and updated guide","volume":"15","author":"Cianfrone G.","year":"2011","journal-title":"Eur. 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