{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:21:32Z","timestamp":1761718892133,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>France is experiencing an increase in the number of opioid prescriptions and related fatalities. We carried out a retrospective observational study using data from the Paris PCC over a 10\u2010year period. The main objective was to obtain an epidemiological description of the severe reported cases. The secondary objectives were to assess the evolution of the number of these cases and their severity defined by the use of fentanyl and its derivatives, the use of the opioid\u2010poisoning treatment naloxone, and the number of fatalities. During 2008\u20132017, 268\u00a0511 cases were recorded, including 1\u00a0122 cases of opioid\u2010related poisoning that required medical management. These poisonings involved tramadol (43%), codeine (25%), dextropropoxyphene (13%), and morphine (8%); most resulted from self\u2010exposure (60%). During the 10\u2010year study period, 130 opioid\u2010related fatalities were recorded in the Paris area, mainly resulting from suicides (39%) in men and were attributed to morphine (27%), tramadol (24%), and methadone (21%). We did not identify an increase in the number of severe opioid\u2010related poisonings or fatalities or in the use of fentanyl or its derivatives. Conversely, we observed an increase in the use of naloxone, suggesting an increase in the severity of opioid poisonings. Our findings show that, until 2017, the opioid overdose epidemiology in the Paris area is different to that in the USA. The systematic analysis of data from the PCCs could be a good tool for health monitoring. To assess trends in France, a national study over a longer period would also be useful.<\/jats:p>","DOI":"10.1111\/fcp.12534","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T18:37:43Z","timestamp":1579199863000},"page":"495-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trends in severe opioid\u2010related poisonings and fatalities reported to the Paris poison control center \u2013 a 10\u2010year retrospective observational study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-8670","authenticated-orcid":false,"given":"Weniko","family":"Car\u00e9","sequence":"first","affiliation":[{"name":"Poison Control Center AP\u2010HP Fernand Widal Hospital 200 rue du faubourg Saint Denis Paris 75010 France"},{"name":"Department of Internal Medicine Percy military Teaching Hospital 101 avenue Henri Barbusse Clamart 92140 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Langrand","sequence":"additional","affiliation":[{"name":"Poison Control Center AP\u2010HP Fernand Widal Hospital 200 rue du faubourg Saint Denis Paris 75010 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Vodovar","sequence":"additional","affiliation":[{"name":"Poison Control Center AP\u2010HP Fernand Widal Hospital 200 rue du faubourg Saint Denis Paris 75010 France"},{"name":"INSERM UMR\u2010S 1144 4 avenue de l'Observatoire Paris 75006 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Deveaux","sequence":"additional","affiliation":[{"name":"Toxlab Laboratory 7 rue Jacques Cartier Paris 75018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Claude","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology\u2010Toxicology AP\u2010HP Raymond Poincar\u00e9 University Hospital MasSpecLab Mass Spectrometry Platform INSERM UMR 1173 Versailles Saint Quentin University 104 boulevard Raymond Poincar\u00e9 Garches 92380 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"M\u00e9garbane","sequence":"additional","affiliation":[{"name":"INSERM UMR\u2010S 1144 4 avenue de l'Observatoire Paris 75006 France"},{"name":"Department of Medical and Toxicological Critical Care AP\u2010HP Lariboisi\u00e8re Hospital 2 rue Ambroise Par\u00e9 Paris 75010 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Dorandeu","sequence":"additional","affiliation":[{"name":"French Armed Forces Biomedical Research Institute 1 Place du G\u00e9n\u00e9ral Val\u00e9rie Andr\u00e9 Br\u00e9tigny\u2010sur\u2010Orge 91223 France"},{"name":"Val\u2010de\u2010Gr\u00e2ce School 1 place Alphonse Laveran Paris 75005 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"volume-title":"Why do adults misuse prescription drugs?. 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