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In this study, we aimed to compare the effects of angiotensin (Ang) II type 2 (AT<jats:sub>2<\/jats:sub>) selective receptor agonist Compound 21 (C21), MAS receptor agonist AVE 0991, Ang II type 1 (AT<jats:sub>1<\/jats:sub>) selective receptor blocker losartan, and Ang\u2010converting enzyme inhibitor captopril on haemodynamic parameters and infarct size on myocardial ischemia\/reperfusion (MI\/R)\u2010induced necrosis in rats. To induce necrosis in the heart of rats, reperfusion for 2\u00a0h following ischemia for 30\u00a0min to the descending branch of the left main coronary artery was achieved. C21 (0.03\u00a0mg\/kg), AVE 0991 (576\u00a0\u03bcg\/kg), losartan (2\u00a0mg\/kg), and captopril (3\u00a0mg\/kg) were administered as an intravenous infusion at 10\u00a0min before and throughout the ischemia. Then, the infarct size and risk area were calculated from the heart. The percentage of myocardial infarct size to area at risk ratio (%IS\/AR) of groups was Control (MI\/R) group: 48.9\u00a0\u00b1\u00a08.8%; C21 group: 31.1\u00a0\u00b1\u00a07.8%; AVE 0991 group: 29.9\u00a0\u00b1\u00a04.8%; C21\u00a0+\u00a0AVE 0991 group: 28.2\u00a0\u00b1\u00a03.3%; Losartan\u00a0+\u00a0AVE 0991 group: 30.8\u00a0\u00b1\u00a05.8%; Captopril\u00a0+\u00a0AVE 0991 group: 31.7\u00a0\u00b1\u00a07.7%. %IS\/AR of the drug\u2010treated groups decreased significantly when compared to the MI\/R group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Our results indicate that the importance of AT<jats:sub>1<\/jats:sub>, AT<jats:sub>2<\/jats:sub>, and MAS receptors in the MI\/R injury. Inhibition of Ang II formation by captopril, blockade of AT<jats:sub>1<\/jats:sub> receptor with losartan, and stimulation of AT<jats:sub>2<\/jats:sub> receptor with C21 and MAS receptor with AVE 0991 showed beneficial effects by reducing infarct size.<\/jats:p>","DOI":"10.1111\/fcp.12599","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T13:49:49Z","timestamp":1598622589000},"page":"669-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of the effects of losartan, captopril, angiotensin II type 2 receptor agonist compound 21, and MAS receptor agonist AVE 0991 on myocardial ischemia\u2013reperfusion necrosis in rats"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-7849","authenticated-orcid":false,"given":"Onural","family":"Ozhan","sequence":"first","affiliation":[{"name":"Department of Pharmacology Medicine School Inonu 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