{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:50:15Z","timestamp":1790815815991,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As the number and severity of complications related to cocaine use reported to the French Addictovigilance Network have increased, the French health authorities requested a national epidemiologic study of the data collected by this network from 2010 to 2016. For this purpose, the spontaneous reports (SRs) linked to cocaine notified by health professionals were analyzed as well as the data from the pharmacoepidemiological surveys OPPIDUM (observation of illegal drugs and misuse of psychotropic medications) and DRAMES (deaths related to the abuse of licit and illicit psychoactive substances). In total, 1\u00a0265 SRs were analyzed (510% increase from 2010 to 2016). Users were mainly men (952\/1\u00a0261; 75%), with a median age of 35.0\u00a0years [IQ<jats:sub>25\u201375<\/jats:sub>: 28\u201342]. Cocaine was consumed through the intranasal route by 52% of users (416\/797), followed by intravenous administration (32%, 253\/797) and inhalation (24%, 190\/797). The use of cocaine powder and crack cocaine was reported in 70% (475\/674) and 23% (154\/674) of SRs, respectively. Cocaine was consumed with other psychoactive substances and alcohol in 47% (603\/1265) and 60% (387\/649) of cases, respectively. The main cocaine\u2010related complications were psychiatric complications (29%), neurologic complications (24%) and cardiovascular complications (23%). Analysis of the OPPIDUM survey data showed that in 2016, 15.9 and 2.4% of the included subjects consumed cocaine or crack cocaine the week preceding the survey, the highest rate for the 2006\u20132016 period. The DRAMES survey indicated that cocaine\u2010related deaths increased by threefold from 2014 to 2016. These data confirm that cocaine use in France is worrying with an increase in the number of severe complications and deaths.<\/jats:p>","DOI":"10.1111\/fcp.12603","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T14:12:05Z","timestamp":1598623925000},"page":"455-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Health consequences of cocaine use in France: data from the French Addictovigilance Network"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-9811","authenticated-orcid":false,"given":"C\u00e9line","family":"Eiden","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale et Toxicologie Centre d\u2019Addictovigilance CHU Montpellier Univ Montpellier Avenue du Doyen Gaston Giraud Montpellier 34295 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vincent","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale et Toxicologie Centre d\u2019Addictovigilance CHU Montpellier Univ Montpellier Avenue du Doyen Gaston Giraud Montpellier 34295 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Serrand","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique et d'Epid\u00e9miologie CHU Montpellier Univ Montpellier Avenue du Doyen Gaston Giraud Montpellier 34295 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anais","family":"Serre","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale et Toxicologie Centre d\u2019Addictovigilance CHU Montpellier Univ Montpellier Avenue du Doyen Gaston Giraud Montpellier 34295 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Richard","sequence":"additional","affiliation":[{"name":"ANSM Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 Saint\u2010Denis 93285 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Picot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique et d'Epid\u00e9miologie CHU Montpellier Univ Montpellier Avenue du Doyen Gaston Giraud Montpellier 34295 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Frauger","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique et Pharmacovigilance Centre d\u2019Evaluation et d\u2019Information sur la Pharmacodependance Paca Corse H\u00f4pital de la Timone Marseille 13005 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Fouilh\u00e9","sequence":"additional","affiliation":[{"name":"Centre d\u2019Addictovigilance CHU de Grenoble Grenoble cedex 9 38043 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-8630","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Daveluy","sequence":"additional","affiliation":[{"name":"Centre d\u2019Addictovigilance Service de Pharmacologie M\u00e9dicale CHU de Bordeaux INSERM U657 Place Am\u00e9lie Raba\u2010L\u00e9on Bordeaux 33000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Peyri\u00e8re","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale et Toxicologie Centre d\u2019Addictovigilance CHU Montpellier Univ Montpellier Avenue du Doyen Gaston Giraud Montpellier 34295 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the French Addictovigilance Network (FAN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,2]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"EU Drug markets report.2019. 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