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Wistar rats were administered L\u2010methionine (1.7\u00a0g\/kg\/day; p.o. \u00d7 8\u00a0weeks) to induce VCID. Morris water maze (MWM) test was employed to assess learning and memory. Endothelial dysfunction was assessed in the isolated aorta by observing endothelial\u2010dependent vasorelaxation and levels of serum nitrite. Various biochemical and histopathological estimations were also performed. L\u2010methionine produced significant impairment in endothelium\u2010dependent vasorelaxation and decreases serum nitrite levels indicating endothelial dysfunction. Further, these animals performed poorly on MWM, depicting impairment of learning and memory. Further, a significant rise in brain oxidative stress level (indicated by increase in brain thiobarbituric acid\u2010reactive species and decrease in reduced glutathione levels), brain acetylcholinesterase activity, brain myeloperoxidase activity, brain TNF\u2010\u03b1 and IL\u20106 levels, and brain leukocyte (neutrophil) infiltration was also observed. Treatment of ozagrel (10 and 20\u00a0mg\/kg, p. o.)\/donepezil (0.5\u00a0mg\/kg, i.p., serving as standard) ameliorated L\u2010methionine\u2010induced endothelial dysfunction, memory deficits, and biochemical and histopathological changes. It may be concluded that ozagrel markedly improved endothelial dysfunction, learning and memory, and biochemical and histopathological alteration associated with L\u2010methionine\u2010induced VCID and that TXA2 can be considered as an important therapeutic target for the management of VCID.<\/jats:p>","DOI":"10.1111\/fcp.12610","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T07:36:34Z","timestamp":1601969794000},"page":"650-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ameliorative effect of ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia\u2010induced experimental vascular cognitive impairment and dementia"],"prefix":"10.1111","volume":"35","author":[{"given":"Pankaj","family":"Bhatia","sequence":"first","affiliation":[{"name":"CNS Research Lab. 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