{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:43:13Z","timestamp":1761864193450,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004718","name":"Universit\u00e9 de Toulouse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data are lacking on the impact of ACEI\/ARB exposure on unfavorable outcome in the population of patients hospitalized for COVID\u201019 with hypertension\/cardiovascular disease, particularly in Europe. The ACE\u2010CoV study was designed to assess this question. The study was conducted in the Covid\u2010Clinic\u2010Toul cohort, which contains data about all patients hospitalized at Toulouse University hospital, France with a SARS\u2010CoV\u20102 infection since March, 2020. We selected the patients with a history of cardiovascular disease (heart failure or coronary disease) and\/or arterial hypertension. We conducted a subgroup analysis in patients with arterial hypertension. ACEI\/ARB exposures at admission were assessed. The outcome was composite: admission to intensive care unit, need of mechanical ventilation or death during the 14\u00a0days after admission to hospital. We used logistic regression models with propensity scores (PS) weighted by overlap weighting (OW) and inverse probability of treatment weighting (IPTW). Between March 2020 and April 20, 2020, the Covid\u2010Clinic\u2010Toul included 263 patients. Among them, 111 were included in the ACE\u2010CoV study population. In OW\u2010PS\u2010adjusted analyses, the association of exposure to ACEIs or ARBs with outcome occurrence was OR: 1.56 (95% CI: 0.73\u20133.33). It was 0.99 (95% CI: 0.68\u20131.45) for ACEIs and 1.64 (95% CI: 0.77\u20133.50) for ARBs. Analyses with weighting by the IPTW\u2010PS method gave similar results. Results were similar when considering the subgroup of patients with arterial hypertension. The ACE\u2010CoV study found no association between exposure to ACEIs or ARBs and unfavorable outcome in hospitalized patients for COVID\u201019 with a history of cardiovascular disease\/arterial hypertension.<\/jats:p>","DOI":"10.1111\/fcp.12613","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T08:37:23Z","timestamp":1603874243000},"page":"194-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outcome of patients hospitalized for COVID\u201019 and exposure to angiotensin\u2010converting enzyme inhibitors and angiotensin\u2010receptor blockers in France: results of the ACE\u2010CoV study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6010-2891","authenticated-orcid":false,"given":"Margaux","family":"Lafaurie","sequence":"first","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire de Toulouse 37 all\u00e9es Jules Guesde Toulouse 31000 France"},{"name":"Centre d\u2019Investigation Clinique 1436, axe pharmaco\u00e9pid\u00e9miologie Centre Hospitalier Universitaire de Toulouse\u2010Purpan place du Dr Baylac, TSA40031 Toulouse Cedex 9 31059 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Martin\u2010Blondel","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales Centre Hospitalier Universitaire de Toulouse\u2010Purpan place du Dr Baylac Toulouse Cedex 9 TSA40031 31059 France"},{"name":"UMR INSERM\/CNRS 1043 Centre de Physiopathologie Toulouse Purpan 330 avenue de Grande\u2010Bretagne Toulouse cedex 9 31059 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Delobel","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales Centre Hospitalier Universitaire de Toulouse\u2010Purpan place du Dr Baylac Toulouse Cedex 9 TSA40031 31059 France"},{"name":"UMR INSERM\/CNRS 1043 Centre de Physiopathologie Toulouse Purpan 330 avenue de Grande\u2010Bretagne Toulouse cedex 9 31059 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Service des Urgences Centre Hospitalier Universitaire de Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Sommet","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire de Toulouse 37 all\u00e9es Jules Guesde Toulouse 31000 France"},{"name":"Centre d\u2019Investigation Clinique 1436, axe pharmaco\u00e9pid\u00e9miologie Centre Hospitalier Universitaire de Toulouse\u2010Purpan place du Dr Baylac, TSA40031 Toulouse Cedex 9 31059 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9953-4640","authenticated-orcid":false,"given":"Guillaume","family":"Moulis","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique 1436, axe pharmaco\u00e9pid\u00e9miologie Centre Hospitalier Universitaire de Toulouse\u2010Purpan place du Dr Baylac, TSA40031 Toulouse Cedex 9 31059 France"},{"name":"Service de M\u00e9decine Interne salle Le Tallec Centre Hospitalier Universitaire de Toulouse\u2010Purpan place du Dr Baylac, TSA40031 Toulouse Cedex 9 31059 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_13_3_1","unstructured":"World Health Organization WHO.Coronavirus. 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