{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:14:20Z","timestamp":1780938860651,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Buprenorphine has been used in pain and opioid addiction management for nearly 25\u00a0years. Compared to methadone, buprenorphine is thought to exhibit less side effects and respiratory depression in case of accidental or suicidal overdose. The aim was to describe the characteristics of exposures reported to a French Poison Control Center (PCC). We conducted a retrospective study including all buprenorphine exposures for which advice of our PCC was required between 2009 and 2018. After data extraction from the electronic medical files and anonymous transfer to an Access base, a statistical descriptive analysis was performed focusing on adolescents over 10\u00a0years old and adults. One hundred and ninety\u2010nine cases were analyzed. The major circumstances of exposure were suicide attempts and overdoses in patients with previously identified substance abuse. Buprenorphine exposures have been reduced by 50% between 2009 and 2018. Coingestions, often with benzodiazepines or antidepressants, were almost systematic and 79% of all the series exhibited at least one symptom. Among the symptomatic cases, neurological effects were the most frequent (83%) and respiratory symptoms occurred in 13%. No deaths were registered. Severity did not exceed PSS1 in 80% of all the cases. Treatment was mainly symptomatic even though naloxone was required in at least 5% of the symptomatic cases. Within 24\u00a0h after exposure, 120 patients were discharged from the emergency department. Despite loss to follow\u2010up, our results suggest that buprenorphine is relatively safe.<\/jats:p>","DOI":"10.1111\/fcp.12630","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T02:10:37Z","timestamp":1605060637000},"page":"764-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Buprenorphine exposures in adolescents and adults: a 10\u2010year experience of a French Poison Control Center"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7883-3219","authenticated-orcid":false,"given":"Audrey","family":"Boulamery","sequence":"first","affiliation":[{"name":"Service de Pharmacologie Clinique Centre antipoison\u2010Toxicovigilance Hopital Sainte Marguerite APHM Aix\u2010Marseille Universite  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-027X","authenticated-orcid":false,"given":"Katharina","family":"von Fabeck","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique Centre antipoison\u2010Toxicovigilance Hopital Sainte Marguerite APHM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5373-1507","authenticated-orcid":false,"given":"Mathieu","family":"Glaizal","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique Centre antipoison\u2010Toxicovigilance Hopital Sainte Marguerite APHM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-6312","authenticated-orcid":false,"given":"Luc","family":"de Haro","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique Centre antipoison\u2010Toxicovigilance Hopital Sainte Marguerite APHM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-2257","authenticated-orcid":false,"given":"Nicolas","family":"Simon","sequence":"additional","affiliation":[{"name":"INSERM IRD SESSTIM Service de Pharmacologie Clinique Centre antipoison\u2010Toxicovigilance Hopital Sainte Marguerite APHM Aix\u2010Marseille Universite  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12796"},{"key":"e_1_2_6_3_1","first-page":"859","article-title":"Buprenorphine \u2010 an attractive opioid with underutilized potential in treatment of chronic pain","volume":"8","author":"Khanna I.K.","year":"2015","journal-title":"J Pain Res."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.04.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1994.71"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.01.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.731510"},{"issue":"8","key":"e_1_2_6_8_1","first-page":"819","article-title":"Child poisonings with methadone in France: a 6\u2010year prospective national survey since the availability of capsules in 2008","volume":"53","author":"Torrents R.","year":"2015","journal-title":"Clin. Toxicol. (Phila)"},{"key":"e_1_2_6_9_1","unstructured":"deHaroL. TorrentsR. GlaizalM.Intoxications par la M\u00e9thadone AP\u2010HP. Exp\u00e9rience du r\u00e9seau de Toxicovigilance des Centres Antipoison de France(2018).https:\/\/www.ansm.sante.fr\/var\/ansm_site\/storage\/original\/application\/78cd5db4c5530f7e9e248a891a45a941.pdf(last access July 23rd 2020). (Article in French)."},{"issue":"1","key":"e_1_2_6_10_1","first-page":"73","article-title":"Methadone poisonings: a seven\u2010year retrospective study of the French Poison Centers Network focusing on suicide attempts versus misuses","volume":"33","author":"Torrents R.","year":"2019","journal-title":"Fundam. Clin. Pharmacol."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12518"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563659809028940"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2012.11.104"},{"key":"e_1_2_6_14_1","unstructured":"Addictions en r\u00e9gion Provence\u2010Alpes\u2010C\u00f4te d\u2019Azur: Consommation de substances psychoactives et offrem\u00e9dicosociale. (2019).https:\/\/www.ofdt.fr\/BDD\/publications\/docs\/epfxmdz7.pdf(last accessed July 23 2020). (Article in French)."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563216688489"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.02.014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00139709-200625020-00002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1122-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200607000-00012"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:02:36Z","timestamp":1693296156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,16]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/fcp.12630"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12630","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,16]]},"assertion":[{"value":"2020-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}