{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:27:05Z","timestamp":1790731625590,"version":"4.1.0"},"reference-count":261,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cluster headache (CH) is the most common form of trigeminal autonomic cephalalgia. Current treatments have several limitations, and new drugs are required. This article first briefly reviews present acute and preventive treatments in CH, their mechanism of action and limitations, then describes the state of the art in recent clinical drug trials since 2015, and ends with a critique of trials in the CH field. Research is limited by lack of knowledge of pathophysiology and lack of animal models. In the past 5\u00a0years, no brand\u2010new treatment has emerged, but promising drugs, such as CGRP(R) antibodies, are under study. According to the literature and guidelines, clinicians and researchers should be aware of many limitations in study protocols: concomitant medication, patient sample size, patients\u2019 protocol compliance, and study designs that tend to restrict patient recruitment.<\/jats:p>","DOI":"10.1111\/fcp.12636","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T09:20:30Z","timestamp":1607505630000},"page":"595-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cluster headache: state of the art of pharmacological treatments and therapeutic perspectives"],"prefix":"10.1111","volume":"35","author":[{"given":"Pierre","family":"Courault","sequence":"first","affiliation":[{"name":"Lyon Neuroscience Research Center (CRNL) Universit\u00e9 de Lyon CNRS INSERM Lyon France"},{"name":"Hospices Civils de Lyon (HCL) Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Demarquay","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon (HCL) Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-7098","authenticated-orcid":false,"given":"Luc","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center (CRNL) Universit\u00e9 de Lyon CNRS INSERM Lyon France"},{"name":"Hospices Civils de Lyon (HCL) Lyon France"},{"name":"CERMEP\u2010Imaging Platform Groupement Hospitalier Est Bron France"},{"name":"National Institute for Nuclear Science and Technology (INSTN) CEA Saclay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3637-8035","authenticated-orcid":false,"given":"Sophie","family":"Lancelot","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center (CRNL) Universit\u00e9 de Lyon CNRS INSERM Lyon France"},{"name":"Hospices Civils de Lyon (HCL) Lyon France"},{"name":"CERMEP\u2010Imaging Platform Groupement Hospitalier Est Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01592.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0626-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00735-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-S1-P46"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-014-0413-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-008-0022-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30405-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199902000-00001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53491-0.00016-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230214"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/10561"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)02470-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-008-0085-z"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.081836"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100528"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419851815"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0620-2"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.douler.2015.01.001"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12866"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1993.tb04189.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250505"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1991.1104165.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005000"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00748-2"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(91)90630-B"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000654"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70051-6"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb14679.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-09-03423.1999"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1704525.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-3787(05)85109-4"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00570-0"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0170-y"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13643.x"},{"key":"e_1_2_5_37_1","first-page":"167","article-title":"Sumatriptan overuse in episodic cluster headache: lack of adverse events, rebound syndromes, drug dependence and tachyphylaxis","volume":"15","author":"Centonze V.","year":"2000","journal-title":"Funct. Neurol."},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00225.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2010.01.090086"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0134-7"},{"key":"e_1_2_5_41_1","first-page":"201","article-title":"Sumatriptan and ergotamine overuse and drug\u2010induced headache: a clinicoepidemiologic study","volume":"22","author":"Evers S.","year":"1999","journal-title":"Clin. Neuropharmacol."},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050122"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1999.019008735.x"},{"key":"e_1_2_5_44_1","first-page":"92","article-title":"Histaminic cephalgia","volume":"72","author":"Horton B.T.","year":"1952","journal-title":"J. Lancet"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1981.hed2101001.x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060040072015"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000133405.80679.4B"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1855"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416637817"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00450.x"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01501.x"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00447.x"},{"key":"e_1_2_5_53_1","first-page":"311","volume-title":"Migraine and other mechanisms","author":"Hardebo J.E.","year":"1991"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411412087"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01806.x"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1983.hed2306266.x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1989.hed2903167.x"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1990.hed3007411.x"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.6.1382"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00839.x"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000267319.18123.d3"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70186-7"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01566.x"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705456"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13603"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-010-0289-x"},{"issue":"13","key":"e_1_2_5_67_1","first-page":"1","article-title":"High\u2010dose verapamil in episodic and chronic cluster headaches and cardiac adverse events: is it as safe as we think?","volume":"2","author":"Alexandre J.","year":"2015","journal-title":"Drug Saf. Case Rep."},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.11.001"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01298.x"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04196.x"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1981.hed2104132.x"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1706673.x"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(69)90026-5"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3852.466"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90109-5"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb13249.x"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1159\/000467990"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.20.5.513"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.6.2991"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066616651582"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61842-0"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199529030-00004"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181eb58c8"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.1.234"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00665.x"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03137.x"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.63784"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2002.02183.x"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb02163.x"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1083422"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612222"},{"key":"e_1_2_5_92_1","first-page":"375","article-title":"The treatment of cluster headaches with prednisone","volume":"36","author":"Jammes J.L.","year":"1975","journal-title":"Dis. Nerv. Syst."},{"key":"e_1_2_5_93_1","first-page":"159","volume-title":"Migraine Trust. Int. Migraine Symp. London, Sept. Current Concepts in Migraine Research.","author":"Kudrow L.","year":"1976"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1978.hed1804219.x"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414539057"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.07.015"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00992.x"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.09.011"},{"key":"e_1_2_5_99_1","unstructured":"Leiden University Medical Center.GON\u2010injection for a sooner and better treatment of cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04014634(accessed 25 June 2020)."},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-198903000-00010"},{"key":"e_1_2_5_101_1","volume-title":"Final Report: Examination of the Effects of Intrathecally Administered Synthetic and Extracted Capsaicin on the Levels of SP, CBRP and VIP in the Dorsal and Ventral Horns of the Rat Spinal Cord [data on file]","author":"Yaksh T."},{"key":"e_1_2_5_102_1","volume-title":"Final Report: Effects of Intrathecally Administered Galen Capsaicinoid Drugs on Hot Plate and Spinal SP Levels","author":"Yaksh T."},{"key":"e_1_2_5_103_1","first-page":"657","article-title":"Local effects of capsaicin versus civamide, a novel potent neuropeptide depletor","volume":"4","author":"Bernstein J.","year":"1995","journal-title":"J. Invest. Dermatol."},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2000.00088.x"},{"key":"e_1_2_5_105_1","first-page":"27","volume-title":"Cellular Mechanism of the Action of Capsaicin","author":"Bevan S.","year":"1993"},{"issue":"1","key":"e_1_2_5_106_1","first-page":"S119","article-title":"The therapeutic future in headache","volume":"33","author":"Rapoport A.M.","year":"2012","journal-title":"Neurol. Sci. Off. J. Ital. Neurol Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"e_1_2_5_107_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.6.990"},{"key":"e_1_2_5_108_1","unstructured":"CadyR.Pilot study evaluating the use of nasal carbon dioxide for the treatment of cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02381795(accessed 2 May 2020)."},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1978.hed1803122.x"},{"key":"e_1_2_5_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1979.hed1905257.x"},{"key":"e_1_2_5_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1984.hed2401001.x"},{"key":"e_1_2_5_112_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.12.2302"},{"key":"e_1_2_5_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1992.hed3203126.x"},{"key":"e_1_2_5_114_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.7.984"},{"key":"e_1_2_5_115_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1996.3603174.x"},{"key":"e_1_2_5_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1995.hed3501038.x"},{"key":"e_1_2_5_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00850.x"},{"key":"e_1_2_5_118_1","unstructured":"Pharmaceuticals C.C.H.Effect of ketamine intranasal spray in treatment of chronic cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04179266(accessed 6 May 2020)."},{"key":"e_1_2_5_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tacc.2014.03.002"},{"key":"e_1_2_5_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.624"},{"key":"e_1_2_5_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00482-016-0111-z"},{"key":"e_1_2_5_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13135"},{"key":"e_1_2_5_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03016530"},{"key":"e_1_2_5_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12099"},{"key":"e_1_2_5_125_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170227115019"},{"key":"e_1_2_5_126_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200002000-00031"},{"key":"e_1_2_5_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12094"},{"key":"e_1_2_5_128_1","first-page":"52","article-title":"Ketamine as treatment for depression","volume":"133","author":"Taiminen T.","year":"2017","journal-title":"Duodecim Laaketieteellinen Aikakauskirja"},{"key":"e_1_2_5_129_1","first-page":"e5912","article-title":"Depression among patients with chronic cluster headaches","volume":"11","author":"Jumani L.","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_5_130_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.17f11681"},{"key":"e_1_2_5_131_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014548872"},{"key":"e_1_2_5_132_1","doi-asserted-by":"crossref","unstructured":"CrespiJ. BratbakD. DodickD.W.et al.Open\u2010label multi\u2010dose pilot safety study of injection of onabotulinumtoxina toward the otic ganglion for the treatment of intractable chronic cluster headache. Headache. (2020)601632\u20131643.","DOI":"10.1111\/head.13889"},{"key":"e_1_2_5_133_1","unstructured":"Norwegian University of Science and Technology.Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment\u2010refractory Chronic Cluster Headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03944876(accessed 29 April 2020)."},{"key":"e_1_2_5_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007818"},{"key":"e_1_2_5_135_1","unstructured":"GiniesP. FraimoutJ. KongA.et al.Treatment of cluster headache by subcutaneous injection of botulinum toxin. 8thWorld Congress on Pain 1996. Poster presentation: 50."},{"key":"e_1_2_5_136_1","first-page":"332","article-title":"Botulinum toxin type A in the treatment of headache syndromes: a clinical report of 79 patients","volume":"20","author":"Smuts J.","year":"2000","journal-title":"Cephalalgia"},{"key":"e_1_2_5_137_1","first-page":"329","article-title":"The use of botulinum toxin\u2010A in the treatment of refractory cluster headache: case reports","volume":"20","author":"Freund B.","year":"2000","journal-title":"Cephalgia"},{"key":"e_1_2_5_138_1","unstructured":"RobbinsL.Botulinum toxin for cluster headache. Poster presentation at the 10th Congress of the International Headache Society New York NY."},{"key":"e_1_2_5_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-007-0400-0"},{"key":"e_1_2_5_140_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415597891"},{"key":"e_1_2_5_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13398"},{"key":"e_1_2_5_142_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0874-y"},{"key":"e_1_2_5_143_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410364676"},{"key":"e_1_2_5_144_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.2444"},{"key":"e_1_2_5_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11080459"},{"key":"e_1_2_5_146_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200211001-00009"},{"key":"e_1_2_5_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12372"},{"key":"e_1_2_5_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13366"},{"key":"e_1_2_5_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.02.011"},{"key":"e_1_2_5_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-013-1150-6"},{"key":"e_1_2_5_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1146"},{"key":"e_1_2_5_152_1","first-page":"307","article-title":"Botulinum toxin: application, safety, and limitations","volume":"364","author":"Bigalke H.","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_2_5_153_1","unstructured":"Zosano Pharma Corporation.Double\u2010blind comparison of the efficacy and safety of C213 to placebo for the acute treatment of cluster headaches.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04066023(accessed 6 May 2020)."},{"key":"e_1_2_5_154_1","unstructured":"Xijing Hospital.Efficacy and safety of zolmitriptan by sublingual administration in the treatment of cluster headache: a multi\u2010center randomized cross\u2010controlled trial.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03377257(2017 accessed 22 September 2020)."},{"key":"e_1_2_5_155_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6749"},{"key":"e_1_2_5_156_1","article-title":"Triptans for acute cluster headache","volume":"008042","author":"Law S.","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_5_157_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.2223"},{"key":"e_1_2_5_158_1","unstructured":"Fda U.S. Zecuity\u00ae.Full prescribing information. US Food and Drug Administration https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/202278s001s002lbl.pdf(2014 accessed 5 May 2020)."},{"key":"e_1_2_5_159_1","unstructured":"Urgent\u2013 Zecuity\u00ae(Sumatriptan Iontophoretic Transdermal System) \u2010 Suspension of Marketing https:\/\/www.fda.gov\/media\/98226\/download(2016 accessed 5 May 2020)."},{"key":"e_1_2_5_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13424"},{"key":"e_1_2_5_161_1","unstructured":"University Hospital Basel Switzerland.Lysergic acid diethylamide (LSD) as treatment for cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03781128(accessed 18 April 2020)."},{"key":"e_1_2_5_162_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219761.05466.43"},{"key":"e_1_2_5_163_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415583145"},{"key":"e_1_2_5_164_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412458190"},{"key":"e_1_2_5_165_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418804160"},{"key":"e_1_2_5_166_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2015.1107664"},{"key":"e_1_2_5_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-017-0186-6"},{"key":"e_1_2_5_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2008.00059.x"},{"key":"e_1_2_5_169_1","first-page":"320","article-title":"Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs","volume":"43","author":"Monsma F.J.","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_5_170_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3452"},{"key":"e_1_2_5_171_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.6.2184"},{"key":"e_1_2_5_172_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0205102"},{"key":"e_1_2_5_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3939"},{"key":"e_1_2_5_174_1","first-page":"279","article-title":"Recurrence of cluster headache with pramipexole","volume":"110","author":"Ossemann M.","year":"2010","journal-title":"Acta Neurol. Belg."},{"key":"e_1_2_5_175_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2003.00549.x"},{"key":"e_1_2_5_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01103.x"},{"key":"e_1_2_5_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13673"},{"key":"e_1_2_5_178_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245940"},{"key":"e_1_2_5_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/252588a0"},{"key":"e_1_2_5_180_1","unstructured":"Yale University.Psilocybin for the treatment of cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02981173(accessed 28 April 2020)."},{"key":"e_1_2_5_181_1","unstructured":"KnudsenG.M.Prophylactic effects of psilocybin on chronic cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04280055(accessed 28 April 2020)."},{"key":"e_1_2_5_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0107-10"},{"key":"e_1_2_5_183_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.024240"},{"key":"e_1_2_5_184_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410363490"},{"key":"e_1_2_5_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2003.11.002"},{"key":"e_1_2_5_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.10.029"},{"key":"e_1_2_5_187_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119598109"},{"key":"e_1_2_5_188_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00177"},{"key":"e_1_2_5_189_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413480752"},{"key":"e_1_2_5_190_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413480753"},{"key":"e_1_2_5_191_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412458188"},{"key":"e_1_2_5_192_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1150082"},{"key":"e_1_2_5_193_1","unstructured":"Novartis Pharmaceuticals.Safety and efficacy study of SOM230 s.c. in cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02619617(accessed 6 May 2020)."},{"key":"e_1_2_5_194_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.3_Suppl.S1"},{"key":"e_1_2_5_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90048-4"},{"key":"e_1_2_5_196_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88581-5_49"},{"key":"e_1_2_5_197_1","unstructured":"KumarU. GrantM. RehfeldJ.et al.Cellular peptide hormone synthesis and secretory pathways."},{"key":"e_1_2_5_198_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02909410","article-title":"A pharmacological approach to the analgesizing mechanism of somatostatin in cluster headache","volume":"17","author":"Caleri D.","year":"1987","journal-title":"Ric. Clin. Lab."},{"key":"e_1_2_5_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20210"},{"key":"e_1_2_5_200_1","unstructured":"Teva Branded Pharmaceutical Products RandD Inc.A Study to Evaluate the Efficacy and Safety of TEV\u201048125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02945046(accessed 22 April 2020)."},{"key":"e_1_2_5_201_1","unstructured":"Teva Branded Pharmaceutical Products RandD Inc.A Study Comparing the Efficacy and Safety of Fremanezumab (TEV\u201048125) for the Prevention of Chronic Cluster Headache (CCH).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02964338(accessed 22 April 2020)."},{"key":"e_1_2_5_202_1","unstructured":"Teva Branded Pharmaceutical Products RandD Inc.A study to explore the long\u2010term safety and efficacy of TEV\u201048125 (Fremanezumab) for the prevention of cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03107052(accessed 22 April 2020)."},{"key":"e_1_2_5_203_1","unstructured":"Eli Lilly and Company.A study of LY2951742 (Galcanezumab) in participants with cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02797951(accessed 24 April 2020)."},{"key":"e_1_2_5_204_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813440"},{"key":"e_1_2_5_205_1","article-title":"Phase 3 randomized, placebo\u2010controlled study of galcanezumab in patients with chronic cluster headache: Results from 3\u2010month double\u2010blind treatment","volume":"333102420905321","author":"Dodick D.W.","year":"2020","journal-title":"Cephalalgia Int. J. Headache"},{"key":"e_1_2_5_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"e_1_2_5_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/308653a0"},{"key":"e_1_2_5_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/313054a0"},{"key":"e_1_2_5_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90296-4"},{"key":"e_1_2_5_210_1","first-page":"129","article-title":"Anti\u2010CGRP in cluster headache therapy","volume":"40","author":"Giani L.","year":"2019","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"issue":"1","key":"e_1_2_5_211_1","first-page":"89","article-title":"New treatments for headache","volume":"35","author":"Vollbracht S.","year":"2014","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"e_1_2_5_212_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00740"},{"key":"e_1_2_5_213_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0576-17.2017"},{"key":"e_1_2_5_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.127"},{"key":"e_1_2_5_215_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000191"},{"key":"e_1_2_5_216_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0408-3"},{"key":"e_1_2_5_217_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417741297"},{"key":"e_1_2_5_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00097-X"},{"key":"e_1_2_5_219_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.3.427"},{"key":"e_1_2_5_220_1","unstructured":"Commissioner O of the.FDA approves first treatment for episodic cluster headache that reduces the frequency of attacks. FDA https:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010approves\u2010first\u2010treatment\u2010episodic\u2010cluster\u2010headache\u2010reduces\u2010frequency\u2010attacks(2020 accessed 25 April 2020)."},{"key":"e_1_2_5_221_1","unstructured":"Emgality F.R.A.N.C.I.S.C.O.E.M.Pending EC decision. European Medicines Agency https:\/\/www.ema.europa.eu\/en\/medicines\/human\/summaries\u2010opinion\/emgality(2020 accessed 25 April 2020)."},{"key":"e_1_2_5_222_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.227793"},{"key":"e_1_2_5_223_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13832"},{"key":"e_1_2_5_224_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000806"},{"key":"e_1_2_5_225_1","unstructured":"KhatamiR.Sodium oxybate in patients with episodic and chronic cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02637648(accessed 21 April 2020)."},{"key":"e_1_2_5_226_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13567"},{"key":"e_1_2_5_227_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822313c6"},{"key":"e_1_2_5_228_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12068"},{"key":"e_1_2_5_229_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra044047"},{"key":"e_1_2_5_230_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182231445"},{"key":"e_1_2_5_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.06.017"},{"key":"e_1_2_5_232_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27549"},{"key":"e_1_2_5_233_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0169-4"},{"key":"e_1_2_5_234_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412473667"},{"key":"e_1_2_5_235_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738250"},{"key":"e_1_2_5_236_1","unstructured":"Autonomic Technologies Inc.Pathway CH S&E Registry: Data Collection on the ATI Neurostimulation System: SPG Stimulation for Cluster Headache \u2010 ATI Neurostimulation System is Branded Internationally as PulsanteTM Microstimulator System. (2018)https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02440776(accessed 22 June 2020)."},{"key":"e_1_2_5_237_1","unstructured":"Beijing Tiantan Hospital.The efficacy and safety of sphenopalatine ganglion pulsed radiofrequency treatment for cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03567590(accessed 23 June 2020)."},{"key":"e_1_2_5_238_1","unstructured":"Weill Medical College of Cornell University.Intra\u2010arterial sphenopalatine ganglion block for patients with refractory headache. (2020)https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04353505(accessed 22 June 2020)."},{"key":"e_1_2_5_239_1","unstructured":"ClinicA.G.Physiotherapy program for cluster headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02460003(accessed 23 June 2020)."},{"key":"e_1_2_5_240_1","unstructured":"LORENZO CD.Efficacy of modified atkins ketogenic diet in chronic cluster headache. A prospective case series. (2017)https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03244735(accessed 22 June 2020)."},{"key":"e_1_2_5_241_1","unstructured":"St. Olavs Hospital.Continuous positive airway pressure as a potential new treatment for CluSt. r headache.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03397563(accessed 23 June 2020)."},{"key":"e_1_2_5_242_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-16-S1-A99"},{"key":"e_1_2_5_243_1","unstructured":"SnoerA.The effect of PACAP\u201038 infusion in inducing headache in patients with cluster headache. (2019)https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03814226(accessed 22 June 2020)."},{"key":"e_1_2_5_244_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1675"},{"key":"e_1_2_5_245_1","unstructured":"The University of Texas Health Science Center Houston.Pain biomarker study.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03511846(accessed 23 June 2020)."},{"key":"e_1_2_5_246_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418815506"},{"key":"e_1_2_5_247_1","unstructured":"Lund M Ph d\u2010student Nunu.Sleep in cluster headache: sleep parameters in\u2010 and outside a cluster bout. (2018)https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03439722(accessed 22 June 2020)."},{"key":"e_1_2_5_248_1","unstructured":"Nordlandssykehuset H.F.Actigraphy and nocturnal heartrate variability in cluster headache patients.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03010189(accessed 23 June 2020)."},{"key":"e_1_2_5_249_1","unstructured":"Samsung Medical Center.Long\u2010term prognosis of cluster headache: a retrospective cohort study.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02895256(accessed 23 June 2020)."},{"key":"e_1_2_5_250_1","unstructured":"BurishM.J.The will erwin headache research center study of cluster headache and trigeminal neuralgia. (2019)https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02910323(accessed 22 June 2020)."},{"key":"e_1_2_5_251_1","unstructured":"Centre Hospitalier Universitaire de Saint Etienne.AVASNA\u202f: Variability of the Autonomic Nervous System (ANS) During Cluster Headache (CH). (2020)https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04439409(accessed 22 June 2020)."},{"key":"e_1_2_5_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00432-8"},{"key":"e_1_2_5_253_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00649.x"},{"key":"e_1_2_5_254_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014992"},{"key":"e_1_2_5_255_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01864.x"},{"key":"e_1_2_5_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00071-9"},{"key":"e_1_2_5_257_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000578"},{"key":"e_1_2_5_258_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws249"},{"key":"e_1_2_5_259_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0963-6"},{"key":"e_1_2_5_260_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00531.x"},{"key":"e_1_2_5_261_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01772.x"},{"key":"e_1_2_5_262_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1995.1506452.x"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12636","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:13:36Z","timestamp":1693206816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,24]]},"references-count":261,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/fcp.12636"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12636","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"value":"0767-3981","type":"print"},{"value":"1472-8206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,24]]},"assertion":[{"value":"2020-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}