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Twenty\u2010eight Wistar rats were randomly divided into a total of four groups as penicillin control and edaravone pretreatment groups (1, 10, and 30mg\/kg). Firstly, permanent electrodes for electrocorticography (ECoG) recording and canula for penicillin injection were placed as stereotactic under anesthesia. At the end of the recovery period, edaravone pretreatment groups received different doses of edaravone by intraperitoneal injection for 14 days and before 30\u2010min penicillin microinjection. Epileptiform activity was induced by injecting 500 IU penicillin through the intracortical cannula. The effects of edaravone pretreatment on epileptiform activity were evaluated by using both electrophysiological and behavioral parameters. Edaravone pretreatment suppressed epileptiform activity by reducing the mean spike frequency and the behavior scores in ECoG recording. The results of the present study indicated that the use of chronic edaravone had an anticonvulsant effect on penicillin\u2010induced focal onset epileptic activity. Edaravone had an anticonvulsant effect even at low doses.<\/jats:p>","DOI":"10.1111\/fcp.12651","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T06:25:50Z","timestamp":1611383150000},"page":"861-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anticonvulsive effects of edaravone on penicillin\u2010induced focal onset seizure model in the conscious rats"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0352-4825","authenticated-orcid":false,"given":"Semiha","family":"Kurt","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine Tokat Gaziosmanpasa University Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Aygun","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine Tokat Gaziosmanpasa University Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00265-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004418"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13783"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.11.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.1591"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-009-0061-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1939"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-014-0125-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.07.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(89)90003-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90288-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.03.021"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.11.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(74)90126-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.55782\/ane-2014-1992","article-title":"Effect of levetiracetam on penicillin induced epileptic activity in rats","volume":"74","author":"Ar\u0131k AE","year":"2014","journal-title":"Acta Neurobiol Exp"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132812Y.0000000004"},{"key":"e_1_2_9_18_1","first-page":"13","article-title":"The effect of varying doses of intravenous paracetamol on the electrical activity of the brain in penicillin\u2010induced status epilepticus in rats","volume":"21","author":"Mumcuo\u011flu \u0130","year":"2015","journal-title":"Epilepsia"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1156"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.06.039"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000479"},{"key":"e_1_2_9_22_1","first-page":"239","article-title":"Neuroprotective effect of edaravone in experimental glaucoma model in rats: a immunofluorescence and biochemical analysis","volume":"8","author":"Aksar AT","year":"2015","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12556"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.05.017"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0166-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00322.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70153-9"},{"key":"e_1_2_9_28_1","first-page":"332","volume-title":"Epilepsy and Other Seizure Disorders. 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