{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:10:58Z","timestamp":1790381458615,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several papers have reported that tramadol can induce hypoglycemia. However, in some reports, confounding factors can be found, like coadministration of hypoglycemic drugs. We used the WHO pharmacovigilance database (VigiBase<jats:sup>\u00ae<\/jats:sup>) to investigate whether tramadol alone could be associated with hypoglycemia. All 2010\u20132019 ICSRs (Individual Case Safety Reports) with the PT term \u201chypoglycemia\u201d and tramadol were included. Two disproportionality analyses were performed: 1\/after inclusion of all reports, 2\/after exclusion of concomitant hypoglycemic drugs. Results are expressed as Reporting Odds Ratios (ROR; 95% CI). Among 10\u00a0038\u00a0436 ICSRs, 97\u00a0639 were included. In comparison with codeine, a significant association was found between tramadol use and reports of hypoglycemia before [ROR\u00a0=\u00a01.54 (1.43\u20131.66)] or after [ROR\u00a0=\u00a01.43 (1.31\u20131.56)] exclusion of hypoglycemic drugs. Tramadol use is associated with a higher risk of hypoglycemia reports than codeine, the other step 2 analgesic, in the presence as well as in the absence of other hypoglycemic drugs. We concluded that hypoglycemia is an adverse drug reaction of tramadol, which can be observed in diabetic as well as in non\u2010diabetic patients.<\/jats:p>","DOI":"10.1111\/fcp.12655","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T08:38:00Z","timestamp":1611909480000},"page":"933-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tramadol\u2010induced hypoglycemia: A pharmacovigilance study"],"prefix":"10.1111","volume":"35","author":[{"given":"Claire","family":"De Canecaude","sequence":"first","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de Pharmacovigilance de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de Pharmacovigilance de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Sommet","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de Pharmacovigilance de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-6001","authenticated-orcid":false,"given":"Jean\u2010Louis","family":"Montastruc","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre de Pharmacovigilance de Pharmaco\u00e9pid\u00e9miologie et d\u2019Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"355","volume-title":"Goodman and Gilman\u2019s The Pharmacological Basis of Therapeutics","author":"Yaksh T","year":"2018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.12.2815"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03472.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04451.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.6512"},{"key":"e_1_2_9_7_1","first-page":"16","article-title":"Hypoglycemic effects of tramadol analgesia in hospitalized patients: a case\u2010control study","volume":"24","author":"Golightly LK","year":"2017","journal-title":"J Diabetes Metab Disord"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48955-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2019.1646246"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1756773"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2020.02.022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2019.09.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04037.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2019.01.006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/11538290-000000000-00000"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14401"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00068-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90547-X"}],"container-title":["Fundamental &amp; 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