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According to these principles, chronopharmacology takes into account the individual differences in patients\u2019 clocks, the rhythmic changes in the organism sensitivity to therapeutic and side effects of drugs, and the predictable time variations of disease. This review examines the current literature on chronopharmacology of neurological diseases focusing its scope on epilepsy, Alzheimer and Parkinson diseases, and neuropathic pain, even if other neurological diseases could have been analyzed. While the results of the studies discussed in this review point to a potential therapeutic benefit of chronopharmacology in neurological diseases, the field is still in its infancy. Studies including a sufficiently large number of patients and measuring gold standard markers of the circadian rhythmicity are still needed to evaluate the beneficial effect of administration times over the 24\u2010hour day but also of clock modulating drugs.<\/jats:p>","DOI":"10.1111\/fcp.12659","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T17:58:38Z","timestamp":1612547918000},"page":"564-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Can chronopharmacology improve the therapeutic management of neurological diseases?"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-8029","authenticated-orcid":false,"given":"Benoit","family":"Sion","sequence":"first","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne INSERM U1107 NEURO\u2010DOL Clermont\u2010Ferrand 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