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Duration of alcohol addiction was longer in BZD users: (33 \u00b1 27 years vs. 29 \u00b1 11 years; <jats:italic>P<\/jats:italic> = 0.001). BZD misuse was noted in 27 patients consuming benzodiazepines (36% of BZD users and 18% of all included patients), mainly increase in the dose (on average, 3 \u00b1 4 times the prescribed dose). The most frequently misused benzodiazepines were diazepam (43.2%), alprazolam (18.9%), and lormetazepam (13.5%). The frequency of patients with lifetime use of cocaine or heroin was higher among BZD misusers than among non\u2010misusers (84.6% vs. 42.2%; &lt;0.01 and 53.9% vs. 27.1%; <jats:italic>P<\/jats:italic> = 0.04). The frequency of patients consuming cocaine in the last month was higher in BZD misusers than in others: 16% versus 6%, <jats:italic>P<\/jats:italic> = 0.002. In multivariate analysis, age (OR=1.65 for 5 years, 95% CI = 1.19\u20132.27; <jats:italic>P<\/jats:italic> = 0.023), psychiatric comorbidities (at least one comorbidity: OR=6.03, 95% CI = 1.40\u201325.83; <jats:italic>P<\/jats:italic> = 0.015) and lifetime cocaine consumption (OR=4.37, 95% CI = 1.21\u201315.86; <jats:italic>P<\/jats:italic> = 0.025) were independently associated with BZD misuse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BZD prescription for long periods might result in tolerance and dose increase. Educational therapy, prescribers\u2019 awareness, and development of therapeutic alternatives are essential to limit BZD misuse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.12678","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T07:15:40Z","timestamp":1617347740000},"page":"1133-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of benzodiazepine misuse and comorbidities in patients with alcohol use disorder"],"prefix":"10.1111","volume":"35","author":[{"given":"Elodie","family":"Lopez","sequence":"first","affiliation":[{"name":"D\u00e9partement d\u2019Addictologie et complications somatiques des addictions CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Jeanne","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Addictologie et complications somatiques des addictions CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure\u2010H\u00e9l\u00e8ne","family":"Lefort","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Addictologie et complications somatiques des addictions CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Autissier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de l\u2019Information M\u00e9dicale CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Picot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de l\u2019Information M\u00e9dicale CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-9099","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Peyri\u00e8re","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie M\u00e9dicale et Toxicologie Centre d\u2019Addictovigilance CHU Montpellier  Montpellier France"},{"name":"INSERM U 1058 Pathogenesis and Control of Chronic Infections (PCCI)  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Donnadieu\u2010Rigole","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Addictologie et complications somatiques des addictions CHU Montpellier  Montpellier France"},{"name":"INSERM U 1058 Pathogenesis and Control of Chronic Infections (PCCI)  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization Management of Substance Abuse Team.Global status report on alcohol and health 2018.https:\/\/www.who.int\/substance_abuse\/publications\/global_alcohol_report\/en\/. 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