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Studies of any design were eligible for inclusion provided that they (i) made use of at least one component of the French health insurance database and (ii) focused on a topic in near and far connection with the field of mental health in France. Database used, design and methods, study period, population, key findings, and type of use for medical research were described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 152\u00a0studies were included in the review analysis. There was an increase in the number of published articles over time throughout the studied period. Studies focusing on adults (<jats:italic>n<\/jats:italic>\u00a0=\u00a0139) largely outnumbered those focusing on children and adolescents (<jats:italic>n<\/jats:italic>\u00a0=\u00a011). Pharmacoepidemiological studies were by far the most frequent (<jats:italic>n<\/jats:italic>\u00a0=\u00a0123), followed by methodological studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a023), epidemiological studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a017), and health economics studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a03). The most studied psychotropic drugs were antidepressants (<jats:italic>n<\/jats:italic>\u00a0=\u00a027), anxiolytics (<jats:italic>n<\/jats:italic>\u00a0=\u00a027), and opioids (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) while fewer studies focused on methylphenidate (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) and on mood stabilizers (<jats:italic>n<\/jats:italic>\u00a0=\u00a05). Few studies specifically focused on psychiatric disorders, mainly depression (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), suicide (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), and psychotic disorders (<jats:italic>n<\/jats:italic>\u00a0=\u00a03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This systematic review highlighted a relatively poor exploitation of the <jats:italic>Syst\u00e8me national des donn\u00e9es de sant\u00e9<\/jats:italic> database in the field of psychiatric research with regard to the great possibilities it offers, with a clear lag in certain fields such as epidemiological or health economics studies and in specific populations, in particular children and adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/fcp.12696","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T09:51:49Z","timestamp":1621245109000},"page":"16-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of the French national health insurance information system for research in the field of mental health: Systematic review and perspectives"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-1657","authenticated-orcid":false,"given":"Alexis","family":"Revet","sequence":"first","affiliation":[{"name":"Service Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent CHU de Toulouse  Toulouse France"},{"name":"CERPOP Inserm UPS Universit\u00e9 de Toulouse  Toulouse France"},{"name":"CIC 1436 Team PEPSS \u201cPharmacologie En Population cohorteS et biobanqueS\u201d Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Moulis","sequence":"additional","affiliation":[{"name":"CIC 1436 Team PEPSS \u201cPharmacologie En Population cohorteS et biobanqueS\u201d Toulouse University Hospital  Toulouse France"},{"name":"Service de M\u00e9decine Interne Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Raynaud","sequence":"additional","affiliation":[{"name":"Service Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent CHU de Toulouse  Toulouse France"},{"name":"CERPOP Inserm UPS Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston MA USA"},{"name":"Caen University Hospital University of Caen Normandy  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-5873","authenticated-orcid":false,"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[{"name":"CIC 1436 Team PEPSS \u201cPharmacologie En Population cohorteS et biobanqueS\u201d Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Mental Health Burden \u2010 World Health Organization.https:\/\/www.who.int\/health\u2010topics\/mental\u2010health#tab=tab_2. 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