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Recently, we proved the anti\u2010inflammatory and antioxidant effects of 5\u2010hydroxytryptamine (5\u2010HT)1B\/1D receptors in intestinal IR injury in rats. Also, the alpha7 nicotinic acetylcholine (\u03b17\u2010nACh) receptor has anti\u2010inflammatory effects in different inflammation\u2010associated injuries. Starting from these premises, we aimed to examine the function of the \u03b17\u2010nACh receptors and the functional interactions between the anti\u2010inflammatory and antioxidant effects of \u03b17\u2010nACh and 5\u2010HT1B\/1D receptors in acute intestinal IR injury. To confirm the expression and localization of \u03b17\u2010nACh receptors on the ileum nerves, an immunofluorescence\u2010based method was applied. Then, intestinal IR injury was induced by 30\u2010min occlusion of superior mesenteric artery and reperfusion for 2\u00a0h in rats. Acute systemic administration of \u03b17\u2010nACh receptor agonist PNU\u2010282987 and antagonist methyllycaconitine, and 5\u2010HT1B\/1D receptors agonist (sumatriptan) and antagonist (GR127, 935) were used in the model of intestinal IR injury. Finally, biochemical and histological parameters were assessed. \u03917\u2010nACh receptors were expressed by 9% on the ileum nerves. Likewise, activation of the \u03b17\u2010nACh receptor showed anti\u2010inflammatory and antioxidant effects in intestinal IR injury but not as well as 5\u2010HT1B\/1D receptors. Interestingly, 5\u2010HT1B\/1D receptors via attenuation of glutamate (Glu) release indirectly activated the \u03b17\u2010nACh receptor and its protective effects against inflammation and oxidative stress. The protective effect of the \u03b17\u2010nACh receptor on intestinal IR injury was activated indirectly through the 5\u2010HT1B\/1D receptors\u2019 modulatory impact on Glu release.<\/jats:p>","DOI":"10.1111\/fcp.12705","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T12:57:31Z","timestamp":1622552251000},"page":"100-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The protective effect of \u03b17\u2010nACh receptor and its interaction with 5\u2010HT1B\/1D receptors in acute intestinal ischemia\u2010reperfusion injury in rats"],"prefix":"10.1111","volume":"36","author":[{"given":"Fatemeh","family":"Gharishvandi","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry School of Medicine Tehran University of Medical Sciences  Tehran 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