{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:08:36Z","timestamp":1747184916820,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a 77\u2010year\u2010old man with Parkinson's disease (PD) who experimented for the first time gout crisis after the initiation of levodopa. Levodopa was withdrawn, and colchicine and allopurinol were initiated to treat the gout crisis. Because of PD progression, levodopa was reintroduced, and the patient presented relapse of gout flare. To further explore the association between gout and levodopa, we extracted and synthetized all Individual Case Safety Reports of gout associated with levodopa in the World Health Organization pharmacovigilance database, VigiBase<jats:sup>\u00ae<\/jats:sup>, up to April 2021. 43 cases of gout were reported in VigiBase<jats:sup>\u00ae<\/jats:sup> with drugs from N04BA ATC class. Levodopa was suspected in fifteen cases among which improvement was noticed in six cases (two after levodopa withdrawal, two despite treatment continuation, and two cases lacking details about action taken with levodopa); three cases did not recover; in the remaining six cases, evolution was not known. \u201cHyperuricemia\u201d was not mentioned in the Summary of Product Characteristics of medicine containing levodopa; however, \u201cabnormality biologics test with uric acid\u201d was mentioned. Despite few cases of recovery after reduced doses of levodopa, the above\u2010described case of positive reintroduction was an argument in favor of the role of levodopa in gout flare. This study highlights a potential association between levodopa and gout through an analysis of the cases reported in the WHO pharmacovigilance database.<\/jats:p>","DOI":"10.1111\/fcp.12706","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T16:39:06Z","timestamp":1622565546000},"page":"221-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gout and Levodopa: An unknown adverse effect?"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-597X","authenticated-orcid":false,"given":"Laura","family":"Quarteroni","sequence":"first","affiliation":[{"name":"Pharmacy Unit CHU of Grenoble Alpes  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Gastaldi","sequence":"additional","affiliation":[{"name":"Rheumatology Department H\u00f4pital Sud CHU of Grenoble Alpes  La Tronche France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athan","family":"Baillet","sequence":"additional","affiliation":[{"name":"Rheumatology Department H\u00f4pital Sud CHU of Grenoble Alpes  La Tronche France"},{"name":"Univ. Grenoble\u2010Alpes GREPI TIMC\u2010IMAG (UMR CNRS 5525), UGA  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Moro","sequence":"additional","affiliation":[{"name":"Division of Neurology CHU of Grenoble Boulevard de la Chantourne  La Tronche France"},{"name":"Univ. Grenoble\u2010Alpes Grenoble Institute of Neuroscience  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Allenet","sequence":"additional","affiliation":[{"name":"Pharmacy Unit CHU of Grenoble Alpes  La Tronche France"},{"name":"Univ. Grenoble\u2010Alpes ThEMAS TIMC\u2010IMAG (UMR CNRS 5525), UGA  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8427-8573","authenticated-orcid":false,"given":"Charles","family":"Khouri","sequence":"additional","affiliation":[{"name":"Pharmacovigilance Unit Grenoble Alpes University Hospital  Grenoble France"},{"name":"U 1300\u2010HP2 Laboratory INSERM Univ. Grenoble Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"111","article-title":"[Imputation of the unexpected or toxic effects of drugs. Actualization of the method used in France]","volume":"40","author":"B\u00e9gaud B","year":"1985","journal-title":"Therapie"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2253-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1972.03190270031008"},{"key":"e_1_2_8_5_1","first-page":"55","article-title":"Effect of L\u2010dopa on renal handling of uric acid","volume":"223","author":"Bierer DW","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196912252812619"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.598"},{"key":"e_1_2_8_8_1","first-page":"679","article-title":"Drug\u2010induced hyperuricaemia and gout","volume":"56","author":"Ben Salem C","year":"2016","journal-title":"Rheumatology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00346-9"},{"key":"e_1_2_8_10_1","first-page":"1950","article-title":"The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis","volume":"29","author":"Urano W","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.11.696a"}],"container-title":["Fundamental &amp; Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/fcp.12706","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/fcp.12706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:40:06Z","timestamp":1696614006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/fcp.12706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/fcp.12706"],"URL":"https:\/\/doi.org\/10.1111\/fcp.12706","archive":["Portico"],"relation":{},"ISSN":["0767-3981","1472-8206"],"issn-type":[{"type":"print","value":"0767-3981"},{"type":"electronic","value":"1472-8206"}],"subject":[],"published":{"date-parts":[[2021,6,15]]},"assertion":[{"value":"2021-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}