{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:27:33Z","timestamp":1774348053503,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Delayed\u2010onset T\u2010cell\u2010mediated cutaneous adverse drug reactions are an uncommon but potentially serious result of medication exposures. Identification of culprit medications is crucial, but clinical diagnosis is often difficult. Patch tests and interferon\u2010gamma release assays (IFN\u03b3\u2010RA) were previously reported as potentially useful ancillary tests, while rechallenges remain the reference standard test. We compared the number of positive test results with patch testing and IFN\u03b3\u2010RA for drugs implicated as possible causes of cutaneous reactions. Fifty\u2010one patients with a suspected cutaneous drug eruption underwent patch testing and IFN\u03b3\u2010RA for suspected drugs. Participants were followed up at least 9\u00a0months after the onset of the rash with results compared with the clinical diagnosis. Forty\u2010two patients presented with morbilliform\/eczematous eruptions; five were diagnosed with fixed drug eruption (FDE) and four with erythema multiforme. None had positive patch testing to the drugs tested. A total of 8\/51 (15.6%) patients had positive reaction by the IFN\u03b3\u2010RA, and an additional 11 (21.6%) patients had borderline results. Positive or borderline results were more likely in patients with FDE (80%) than morbilliform\/eczematous eruptions (30.9%) or erythema multiforme (25%). Our study emphasizes the necessity of additional effective ancillary tests in the evaluation of drug eruptions and supports the use of IFN\u03b3\u2010RA for drug testing as a tool for identifying medications associated with cutaneous drug eruptions.<\/jats:p>","DOI":"10.1111\/fcp.12733","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T18:00:14Z","timestamp":1634752814000},"page":"414-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patch testing versus interferon\u2010gamma release assay in evaluation of drug eruptions"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-8506","authenticated-orcid":false,"given":"Yehonatan","family":"Kaplan","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Sprecher","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Human Molecular Genetics and Biochemistry Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Slodownik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","first-page":"765","article-title":"Rates of cutaneous reactions to drugs","volume":"137","author":"Bigby M","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01017.x"},{"issue":"3","key":"e_1_2_7_5_1","first-page":"278","article-title":"Drug eruptions: approaching the diagnosis of drug\u2010induced skin diseases","volume":"2","author":"Nigen S","year":"2003","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.04.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30378-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.827660"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200001050-00003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2017.1319379"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.03.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15509"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12125"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450601.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12142"},{"key":"e_1_2_7_16_1","volume-title":"Patch Testing: Test Concentrations and Vehicles for 4900 Chemicals","author":"Groot AC","year":"2018"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13306"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.10.030"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.049"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"50","article-title":"Clinical and laboratory assays in the diagnosis of cutaneous adverse drug reactions","volume":"6","author":"Goldberg I","year":"2004","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1995.19"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.09.004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/687532"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12842"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.006"}],"container-title":["Fundamental &amp; 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