{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:41:02Z","timestamp":1774557662613,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Accumulating evidence shows that some antidepressants are abused for their psychostimulant effects, but the extent of antidepressants abuse is unknown in subjects with opioid use disorders (OUD). The objective of this work is to assess the prevalence of antidepressant abuse and its correlates in subjects with OUD. Subjects \u226518\u2009year\u2010old in an opiate maintenance treatment (OMT) program who reported using an antidepressant were selected from the OPPIDUM program from 2011 to 2020. The outcome was antidepressant abuse. Antidepressant abusers were identified as subjects reporting at least one of the following behaviors: \u201cdrug abuse,\u201d \u201cconcomitant use of alcohol,\u201d \u201cillegal obtaining,\u201d and \u201cdose higher than recommended in the Summary of Product Characteristics.\u201d Among the 83\u2009040 observations of subjects \u226518\u2009year\u2010old in an OMT program included in the OPPIDUM program from 2011 to 2020, 2708 (3.3%) subjects reported using an antidepressant in monotherapy. Among them, there were 385 (14.2%) abusers. The proportion of abusers was the highest for amitriptyline (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200931, 25.0%). In multivariate analysis, antidepressant abuse was positively associated with amitriptyline (OR 2.07, 95% CI [1.16, 3.73];\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.015), unemployment (OR 1.52, 95% CI [1.16, 2.01];\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003), the use of intravenous route of administration (OR 1.77, 95% CI [1.12, 2.80];\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.014), and the use of benzodiazepines (OR 1.53, 95% CI [1.21, 1.94];\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Clinicians should be aware of the risk of antidepressant abuse when prescribing in subjects with OUD, accounting for their heterogeneous pharmacological properties that may account for their abuse potential.\n                  <\/jats:p>","DOI":"10.1111\/fcp.12738","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T03:33:38Z","timestamp":1637984018000},"page":"436-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antidepressants abuse in subjects with opioid use disorders: A 10\u2010year study in the French OPPIDUM program"],"prefix":"10.1111","volume":"36","author":[{"given":"Robinson Gravier","family":"Dumonceau","sequence":"first","affiliation":[{"name":"Assistance publique \u2013 H\u00f4pitaux de Marseille, Service de pharmacologie clinique Centre d'\u00c9valuation et d'information sur la pharmacod\u00e9pendance \u2013 Addictovigilance PACA Corse  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-9673","authenticated-orcid":false,"given":"Thomas","family":"Soeiro","sequence":"additional","affiliation":[{"name":"Assistance publique \u2013 H\u00f4pitaux de Marseille, Service de pharmacologie clinique Centre d'\u00c9valuation et d'information sur la pharmacod\u00e9pendance \u2013 Addictovigilance PACA Corse  Marseille France"},{"name":"Aix\u2010Marseille Universit\u00e9 Inserm, UMR 1106  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mence","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Assistance publique \u2013 H\u00f4pitaux de Marseille, Service de pharmacologie clinique Centre d'\u00c9valuation et d'information sur la pharmacod\u00e9pendance \u2013 Addictovigilance PACA Corse  Marseille France"},{"name":"Aix\u2010Marseille Universit\u00e9 Inserm, UMR 1106  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline","family":"Giocanti","sequence":"additional","affiliation":[{"name":"Assistance publique \u2013 H\u00f4pitaux de Marseille, Service de pharmacologie clinique Centre d'\u00c9valuation et d'information sur la pharmacod\u00e9pendance \u2013 Addictovigilance PACA Corse  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9lisabeth","family":"Frauger","sequence":"additional","affiliation":[{"name":"Assistance publique \u2013 H\u00f4pitaux de Marseille, Service de pharmacologie clinique Centre d'\u00c9valuation et d'information sur la pharmacod\u00e9pendance \u2013 Addictovigilance PACA Corse  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Mezaache","sequence":"additional","affiliation":[{"name":"Assistance publique \u2013 H\u00f4pitaux de Marseille, Service de pharmacologie clinique Centre d'\u00c9valuation et d'information 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